agents such as hypertonic saline, mannitol, and erdosteine can bring about some improvements in some patients.
Romero et al., "Mucoactive agents for chronic, non-cystic fibrosis lung disease: a systematic review and meta-analysis," Respirology, vol.
Robertson et al., "Cysteamine (Lynovex[R]), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis," Orphanet Journal of Rare Diseases, vol.
Other approaches include drugs with antioxidant effects, drugs that facilitate lung regeneration, and mucoactive
agents for airway mucus hypersecretory diseases.
Sodium Bicarbonate - Sodium bicarbonate is a base that has occasionally been used as a mucoactive
There is little evidence supporting the use of mucoactive
agents such as N-acetylcysteine in AECOPD.
N-acetylcysteine supplementation may have the benefit of reducing the frequency of exacerbations and improving subjective symptoms (Weiss 2008) however has no effect as a mucoactive
agent at 600 mg twice daily (Stoller 2008).
Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive
Moon, "Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive
ribotoxic stressors via RNA-binding protein human antigen R," Toxicological Sciences, vol.
Erdosteine is a thiol antioxidant having mucoactive
properties and the ability to reduce bacterial adhesiveness.