mucin 1

mucin 1

A 265- to 400-kD transmembrane glycoprotein encoded by MUC1 on chromosome 1q21, which is found in milk-fat-globule membranes.

Normal expression
Normal epithelia and perineurial cells, choroid plexus, arachnoid granulation, epithelioid histiocytes.

Abnormal expression
Neoplastic epithelia, meningiomas, mesotheliomas, mesenchymal tumours, some lymphomas, anaplastic large cell lymphomas.
References in periodicals archive ?
The method of use claims secured in patent number 5192020 entitled Use of mannose receptor-bearing antigen presenting cells for the manufacture of medicament for eliciting cytotoxic T cell response to antigen provide for the treatment of patients with dendritic cells that have been pulsed with mannan fusion protein (M-FP) conjugated to an antigen, including but not limited to mucin 1.
Inflammation driven by overexpression of the hypoglycosylated abnormal mucin 1 (MUC1) links inflammatory bowel disease and pancreatitis.
Our work demonstrates that Mucin 1 (MUC1) is a viable drug target, and that inhibition of MUC1 function blocks tumor development and survival of multiple human cancers in preclinical models, including breast, prostate, colon, lung, and pancreatic cancers.