Therefore, the aim of this study was to assess and compare the expression of mucin 1, 4 and 5AC between the various degree of pancreatic intraepithelial neoplasia constituting the precursor lesions of pancreatic cancer and the normal pancreatic ducts.
Incubation with mouse anti human monoclonal CD227 antibody (mucin 1) (clone VU-3C6, AbDSerotec, 1:200 dilution), mouse anti human monoclonal mucin 4 antibody (clone 5B12, AbDSerotec; 1:1000 dilution) and mouse anti human monoclonal mucin 5AC antibody (clone 1-13M1, AbDSerotec, 1:200 dilution) for properly 30, 10 and 30 minutes in room temperature.
Both firm's products target an abnormal form of the autologous cell surface-associated protein, Mucin 1
(MUC1), which is over-expressed in the majority of known tumour types.
Rukavina, "Specific decidual CD14(+) cells hamper cognate NK cell proliferation and cytolytic mediator expression after mucin 1
treatment in vitro" Journal of Reproductive Immunology, vol.
Inflammation driven by overexpression of the hypoglycosylated abnormal mucin 1
(MUC1) links inflammatory bowel disease and pancreatitis.
 Nonstandard abbreviations: CA125, cancer (or carbohydrate) antigen 125; MUC1, mucin 1
; CIC, circulating immune complex; GSTA1, glutathione S-transferase A1; iu, intensity units.
This US patent grant protects the method of composition and the method of use of CVac, which is formulated in a patient's own dendritic cells and then reinjected back into the patient to generate a cytotoxic T cell response against the mucin 1 antigen.
CVac is a personalised immunotherapy composed of a patient's own dendritic cells pulsed with the cancer antigen mucin 1, conjugated to oxidised mannan.
According to the company, the application protects the method of composition and method of use of its CVac for the generation of a cytotoxic T cell response against the mucin 1
According to the company, the claims secured in patent number 5192020 provide for the treatment of patients with dendritic cells that have been pulsed with mannan fusion protein (M-FP) conjugated to an antigen, including but not limited to mucin 1
This CANcer VAccine Study (CANVAS) is reportedly a multi-centre, randomised, placebo-controlled study of CVac in mucin 1
positive, epithelial ovarian cancer patients who have undergone optimal surgery and achieve complete remission after first-line chemotherapy.