moxifloxacin


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Related to moxifloxacin: Moxifloxacin hydrochloride

moxifloxacin

 [mok″sĭ-flok´sah-sin]
a broad-spectrum antibiotic effective against many gram-positive and gram-negative bacteria; administered orally as the hydrochloride salt in the treatment of bacterial complication of chronic bronchitis, acute sinusitis, community-acquired pneumonia, and skin and skin structure infections due to susceptible organisms.

moxifloxacin

(mŏk′sĭ-flŏk′sə-sĭn)
n.
An antibiotic drug of the fluoroquinolone class, C21H24FN3O4, used primarily to treat respiratory, sinus, and skin infections.

moxifloxacin

A fluoroquinolone wide-spectrum antibiotic with activity against both Gram positive and Gram negative organisms. A brand name is Avelox.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.
References in periodicals archive ?
Cows with clinical and subclinical endometritis can be successfully treated with intrauterine infusion of 2000 mg of Moxifloxacin for 3-5 days.
The adjunct of the fluoroquinolone moxifloxacin or the oxazolidinone linezolid occurred in the majority of cases among "slow" responders, which included also the six drug-resistant patients (and in particular, two cases each of "MDR" and "XDR" tuberculosis; only "MDR" and "XDR" episodes were treated with combined moxifloxacin and linezolid (Table 1).
Conclusion: Moxifloxacin based regimen was associated with an early recovery (within 03 days of commencement of treatment) in a significant number of patients with TBM.
The indications for moxifloxacin use are presented in Figure 1.
Female children had more resistance than males against moxifloxacin (p=0.002), ciprofloxacin (p=0.007), ofloxacin (p=0.011), sparfloxacin (p=0.011) and enoxacin (p=0.045).
In this study, two groups of antibiotics including trimethoprim-sulfamethoxazole and some of quinolone members such as ciprofloxacin, gatifloxacin, moxifloxacin and ofloxacin were selected as well-known antimicrobial agents against S.
The eyeballs were fully immersed for 10 min in 15 mL of one of the following commercial solutions: 0.5% moxifloxacin (Vigamox[c], Alcon, Brazil), 0.3% ciprofloxacin (Ciloxan[c], Alcon, Brazil), and 0.3% ofloxacin (Oflox[c], Allergan, Brazil).
The 54 for whom this treatment failed (positive by PCR test-of-cure at day 28 or persistent symptoms before day 28, with no identified reinfection risk) were given moxifloxacin (400 mg/d for 10 d).
The CLSI breakpoints for MICs were used for metronidazole and moxifloxacin, (8) while EUCAST criteria were used for metronidazole and vancomycin.
(16) The greatest increase in consumption was for moxifloxacin, mainly related to its use for the switch from IV to oral treatment in CAP.
Key words: pharmacokinetics, moxifloxacin, tissue concentrations, high-performance liquid chromatography, bioavilability, avian, Japanese quail, Coturnix japonica