moxifloxacin


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Related to moxifloxacin: Moxifloxacin hydrochloride

moxifloxacin

 [mok″sĭ-flok´sah-sin]
a broad-spectrum antibiotic effective against many gram-positive and gram-negative bacteria; administered orally as the hydrochloride salt in the treatment of bacterial complication of chronic bronchitis, acute sinusitis, community-acquired pneumonia, and skin and skin structure infections due to susceptible organisms.

moxifloxacin

/mox·i·flox·a·cin/ (-flok´sah-sin) a fluoroquinoloneantibacterial effective against many gram-positive and gram-negative bacteria; used as the hydrochloride salt.

moxifloxacin

(mŏk′sĭ-flŏk′sə-sĭn)
n.
An antibiotic drug of the fluoroquinolone class, C21H24FN3O4, used primarily to treat respiratory, sinus, and skin infections.

moxifloxacin

an antiinfective.
indications It is used to treat acute bacterial sinusitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis; acute bacterial exacerbation of chronic bronchitis from S. pneumoniae, H. influenzae, H. parainfluenzae, Klebsiella pneumoniae, Staphylococcus aureus, and M. catarrhalis; and community-acquired pneumonia from S. pneumoniae, H. influenzae, Mycoplasma pneumoniae, Chlamydia pneumoniae, and M. catarrhalis.
contraindication Known hypersensitivity to quinolones prohibits its use.
adverse effects Seizures are a life-threatening effect of this drug. Other adverse effects include prolonged QT interval, dizziness, fatigue, insomnia, depression, confusion, increased ALT and AST, flatulence, heartburn, oral candidiasis, dysphagia, pruritus, urticaria, photosensitivity, flushing, fever, chills, tremor, arthralgia, and tendon rupture. Common side effects include headache, restlessness, nausea, diarrhea, and rash.

moxifloxacin

A fluoroquinolone wide-spectrum antibiotic with activity against both Gram positive and Gram negative organisms. A brand name is Avelox.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

moxifloxacin

a fluoroquinolone antibiotic with activity against anaerobic bacteria.
References in periodicals archive ?
Patients who received moxifloxacin were followed up with a PCR test-of-cure at 14 and 28 days.
Some limited data have been published on moxifloxacin pharmacokinetics in animals such as rabbits, broiler chickens, ducks, calves, and sheep.
In SOLITAIRE-IV Cempra reported that grade 3 increase in levels of alanine transaminase (ALT) occurred in 8% of patients on solithromycin and in 3% of patients on moxifloxacin.
The newly developed method has been found to be simpler, accurate, reproducible, efficient and less time consuming, and has been applied successfully for the simultaneous study of levofloxacin and moxifloxacin.
Widespread use of azithromycin and moxifloxacin will select for multidrug-resistant strains; the time for single-drug, one-dose regimens is probably over," said Dr.
Our comparison stated that Moxifloxacin is the most frequently prescribed anti-microbial pre-operatively for IOL implantation.
Out of all the empirical drugs listed in our result, moxifloxacin seems to be a better broad spectrum antibiotic with 86.
2007; Purohit and Sharma, 2007) however reports on the intrauterine use of Moxifloxacin in cows are unavailable.
Prolongation of the QT interval is a rarely seen side effect of moxifloxacin, and in severe cases it may trigger fatal arrhythmias such as Torsades de Pointes (TdP) (1,2).
leprae in mice than pefloxacin and ofloxacin, while moxifloxacin has proven more bactericidal in leprosy patients.