motilin


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to motilin: secretin, Motilium

motilin

 [mo-til´in]
a polypeptide hormone secreted by enterochromaffin cells of the gut; it causes increased motility of several portions of the gut and stimulates pepsin secretion. Its release is stimulated by the presence of acid and fat in the duodenum.

mo·til·in

(mō-til'in), [MIM*158270]
A 22-amino acid polypeptide occurring in duodenal mucosa as a controller of normal gastrointestinal motor activity; in minute (that is, ng) doses, it induces powerful motor activity increases in the fundic gland area and antral pouches of the stomach, with an increase in pepsin output from the fundic gland.
[motility + -in]
References in periodicals archive ?
On the other hand, MTL acts on motilin receptors to initiate phase III of gastric migrating myoelectric complexes to improve intestinal motility [46].
Takeyama, "Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma," Biological and Pharmaceutical Bulletin, vol.
Erythromycin could stimulate gastrointestinal motility because it acts as a motilin receptor agonist in the gut and gallbladder stimulating enteric nerves and smooth muscle and triggering a phase of the migrating myoelectric complex [18].
Takeyama, "Effect of Dai-kenchuto on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma," Biological and Pharmaceutical Bulletin, vol.
By testing the levels of gastrin and motilin in the blood seven days after the operation, the emodin-treated groups had higher levels of gastrointestinal hormones than the other groups (P <0.0001) (Figures 6(c) and 6(d)).
Motilin, a 22-amino acid residue polypeptide secreted by endocrine M cells, has a powerful fundic pouch motor-stimulating activity [11, 12], and SP, a member of tachykinin family of neuropeptides widely distributed throughout the central nervous system (CNS), controls the enteric noncholinergic motor inhibition of the fundus [13].
As to a genetic component in functional constipation, two motilin polymorphisms have been recently investigated in a paediatric population, without significant differences between constipated patients and healthy subjects [10].
Non-fonksiyonel olanlar (diger adiyla PPoma) kromogranin-A, noron spesifik enolaz, pankreatik polipeptid, kalsitonin, ghrelin, norotensin, motilin, insan koryonik gonadotropini gibi cesitli peptidler salgilarlar.
[9] For instance, cholecystokinin secreting cells, motilin secreting M cells, and neurotensin secreting N cells are found in the small intestine, but are absent in the large intestine.
Motilin, present in breast milk, may be one of those responsible for the difference in bowel habits.
After 14 days of feeding, the serum motilin, gastrin and vitamin D levels of both groups all increased, with significant intra-group and inter-group differences.