Although one paper showed the density of mossy fiber was reduced in the stratum lucidum in the CA3 region in patients with schizophrenia , so far there is no report which examined mossy fiber pathfindings (the projection site) in the stratum radiatum and oriens region in the schizophrenia.
As we discussed earlier, structural alterations within the mossy fiber pathway could be a pathophysiological feature shared by epilepsy and schizophrenia.
Ectopic mossy fiber path finding, a novel finding identified in [alpha]-CaMKII hKO mice, is a cellular phenotype that is also reported in epileptic brains.
Ikegaya," Mossy fiber sprouting as a potential therapeutic target for epilepsy," Current Neurovascular Research, vol.
In conclusion, spontaneous activity at hippocampal mossy fiber to CA3 pyramidal cell is significantly higher in Hr as compared to dx mice.
By stimulating mossy fiber in the dentate gyrus (see Materials and Methods), we recorded evoked mf-CA3 synaptic excitatory currents (EPSCs).
EPSCs evoked by minimal mossy fiber stimulation were studied in the failures rate and in the amplitude (see representative traces in Figure 4(a), upper traces in dx mice and lower traces in Hr mice).
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
Long-term potentiation of hippocampal mossy fiber synapses is blocked by postsynaptic injection of calcium chelators.
Johnston, "L-type calcium channels are required for one form of hippocampal mossy fiber LTP," Journal of Neurophysiology, vol.
Nicoll, "The role of [Ca.sup.2+] channels in hippocampal mossy fiber synaptic transmission and long-term potentiation," Neuron, vol.
Izawa, "Axon collaterals of mossy fibers
from the pontine nucleus in the cerebellar dentate nucleus, " Journal of Neurophysiology, vol.