mosaic

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mosaic

 [mo-za´ik]
a pattern made of numerous small pieces fitted together; in genetics, occurrence in an individual of two or more cell populations each having a different chromosome complement.

mo·sa·ic

(mō-zā'ik),
1. Inlaid; resembling inlaid work.
2. The juxtaposition in an organism of genetically different tissues; it may occur normally (as in lyonization, q.v.), or pathologically, as an occasional phenomenon. From somatic mutation (gene mosaicism), an anomaly of chromosome division resulting in two or more types of cells containing different numbers of chromosomes (chromosome mosaicism), or chimerism (cellular mosaicism).
[Mod. L. mosaicus, musaicus, pertaining to the Muses, artistic]

mosaic

(mō-zā′ĭk)
n.
Biology An individual exhibiting mosaicism.

mo·sa′i·cist (mō-zā′ĭ-sĭst) n.
Referring to a sharply-defined tesselated patchwork of one ‘jig-saw’-shaped pattern imposed upon another of different color, tissue apearance or radiologic density
Genetics An individual with 2 or more genotypically or karyotypically distinct cell lines, arising from a single zygote by somatic mutation, crossing-over, or nondisjunction during mitotic division, an event more common in older mothers
Example Normal female mammal heterozygous for different alleles on the X chromosome; because of X chromosome inactivation, such females consist of two cell types, each with a different X chromosome inactivated, which results in a minor, epigenetic difference, in contrast to mosaic Turner syndrome in which some cells have no X chromosome at all
Gynaecology The mosaic pattern refers to vascular changes of interconnecting vessels resulting in a cobblestone or honeycomb surface appearance by colposcopy. Because the pattern is often associated with cervical intraepithelial neoplasia (CIN), a cervix with a mosaic pattern should be biopsied
Informatics A proprietary web browser (Mosaic), which was the first multiplatform browser for Macintosh, Windows, and UNIX. It was partially responsible for the Web’s explosive growth, but has long since faded into obscurity

mosaic

adjective A patchwork of one sharply-defined 'jig-saw'-shaped pattern imposed upon another of different color, tissue pattern or radiologic density noun Genetics An individual with 2 or more genotypically or karyotypically distinct cell lines, arising from a single zygote by somatic mutation, crossing-over, or nondisjunction during mitotic division. See Chimera, Freemartin Ob/Gyn A vascular change of interconnecting vessels resulting in a cobblestone or honeycomb surface appearance by colposcopy, the mosaic pattern is often associated with CIN and mandates biopsy.

mo·sa·ic

(mō-zā'ik)
1. Inlaid; resembling inlaid work.
2. The juxtaposition in an organism of genetically different tissues; it may occur normally (as in lyonization, q.v.), or pathologically, as an occasional phenomenon.
[Mod. L. mosaicus, musaicus, pertaining to the Muses, artistic]

mosaic

  1. any organism exhibiting a mixture of cells of different genetic makeup, such as a GYNANDROMORPH. See INACTIVE-X HYPOTHESIS. Plants showing this phenomenon are known as CHIMAERAS (1).
  2. a pattern of leaf-arrangement in a tree to maximize the exposure of the leaves to sunlight and thus the level of photosynthesis.

Mosaic

A term referring to a genetic situation, in which an individual's cells do not have the exact same composition of chromosomes. In Down syndrome, this may mean that some of the individual's cells have a normal 46 chromosomes, while other cells have an abnormal 47 chromosomes.