mosaicism


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Related to mosaicism: chimerism

mosaicism

 [mo-za´ĭ-sizm]
the presence in an individual of cells derived from the same zygote, but differing in chromosomal constitution.

mo·sa·i·cism

(mō-zā'i-sizm), [MIM*158250]
Condition of being mosaic (2).

mosaicism

(mō-zā′ĭ-sĭz′əm)
n.
A condition in which tissues of genetically different types occur in the same organism.

mosaicism

The phenotype of a multicelled organism, which is composed of cells expressing different genotypes; for instance, women are functionally mosaic due to the X chromosome genes expressed. Mosaicism due to mutation is less common.

mo·sa·i·cism

(mō-zā'i-sizm)
Condition of being mosaic (2).

mosaicism

The state in which two or more genetically different types of cell occur in the same individual. Although the cells are all derived from the same fertilized egg, they do not all possess the same number of chromosomes. In about 1% of cases of DOWN'S SYNDROME there are two different cell lines, one normal and the other with an additional chromosome 21 (trisomy 21). The effect of mosaicism varies with the proportion of cells containing abnormal chromosomes. Compare CHIMERA.

Mosaicism

A genetic condition resulting from a mutation, crossing over, or nondisjunction of chromosomes during cell division, causing a variation in the number of chromosomes in the cells.
Mentioned in: Patau Syndrome
References in periodicals archive ?
Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro.
Thus, unexpectedly, the liver also demonstrated age mosaicism, which points to potential new paths of regenerative research for this organ.
Diagnosis can also be missed because of the low level of mosaicism in peripheral lymphocytes.
Somatic mutations were detected in 38% (11 of 29) of corals evaluated, and the degree of genetic mosaicism was associated positively with clone size and negatively with coral depth (Fig.
Supernumerary marker chromosomes in man: parental origin, mosaicism and maternal age revisited.
Cytogenetic and molecular evidence for cutaneous mosaicism: the ectodermal origin of Blaschko lines.
Becker's nevus associated with chromosomal mosaicism and congenital adrenal hyperplasia.
Currently, Dr Chun is the professor and the senior vice president of Neuroscience Drug Discovery at Sanford Burnham Prebys Medical Discovery Institute as well as leads a team of 25 researchers in the study of genomic mosaicism (DNA sequence variation in brain cells) and lysophospholipid receptor signaling to understand and develop drug treatments for Alzheimer's disease, multiple sclerosis, and hydrocephalus.
In addition to this anomaly, structural and numerical mosaicism are seen rather frequently [1, 3, 4].
Transmission of the disease in females by a lionization results in functional mosaicism of X-linked genes.
The clinical and diagnostic implications of mosaicism in the neurofibromatoses.