Our results show that FAK has a critical role in morphogenesis and its activity is required for a specific morphogenetic movement called epiboly.
During gastrulation, the massive and precisely orchestrated movements of the cells which shape the embryo are called morphogenetic movements (from the Greek words morphi and genesis), he explained.
Their work also sheds light on the mechanical integration of individual morphogenetic movements, ie, how one movement is coupled to others giving rise to the three dimensional architecture of the embryo.
During the gastrula stage, structures are shaped through morphogenetic movement of tissue (mesoderm), injuring and disorganizing the invaded tissue architecture, which in turn promotes consequent proliferation and differentiation.
These phenomena resemble the morphogenetic movement of embryo development, as it follows similar tissue invasive mechanisms through cellular movement and is tailored upon a mesenchymal matrix of mesodermic derived cells ["fluid mesoderm" according to Mechtnikoff (1893)].
This morphogenetic movement is allowed by an elongation of interphase in the epidermal cell cycles.
Regarding the mechanisms underlying this coordination, the regulation of cellular processes such as the cell cycle, cell division, and morphogenetic movement of multicellular bodies must be studied together with cell differentiation.
They complete the symposium by reviewing recent work on simulation of gastrulation and cell cycles as well as on the morphogenetic movements
of the dorsally located 40-cell notochord.
Confocal Microscopic Analysis of Morphogenetic Movements