morphogen


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mor·pho·gen

(mōr'fō-jen),
A soluble molecule secreted at a distance from the target cells that specifies the fates of cells. A morphogen may specify more than one cell type by forming a concentration gradient.

morphogen

(môr′fō-jĕn′)
n.
Any of various chemicals in embryonic tissue that influence the movement and organization of cells during morphogenesis by forming a concentration gradient.

morphogen

(1) Any substance (e.g., retinoic acid) that triggers growth, proliferation and differentiation of cells and tissues in a concentration-dependent fashion. 
(2) Any molecule that orchestrates the development of an organism from the stage of a single cell to early embryogenesis.
References in periodicals archive ?
It is this gradient of morphogens that tells stem cells what type of specialized cell and tissue to become.
With this model, it was possible to understand morphogen's spatio-temporal dynamics and stationary concentration profiles during the process of cap formation from a semi-quantitative point of view.
Zhang et al., "Effects of morphogen and scaffold porogen on the differentiation of dental pulp stem cells," Journal of Endodontics, vol.
Hedgehog morphogens are associated with MPs shed from the plasma membrane of apoptotic stimulated T cells.
Citation: "A microparticle approach to morphogen delivery within pluripotent stem cell aggregates"; Andres M.
The research does not nix the theory - called the morphogen theory - but science may now have a hypothetical tiger by the tail as they try to figure out this aspect of how Nature works.
A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the Pit-1 gene.
Although the detailed mechanism of STS action as a neurogenic morphogen remains unclear, it seems that it is associated with the inhibition of some protein kinases which may contribute to neurite outgrowth [7].
Generation of a novel wing colour pattern by the Wingless morphogen. Nature 464: 1143-1149.
Generation and interpretation of morphogen gradients.
It is likely that all-trans-retinoic acid (produced by cells from vitamin A) is a morphogen and excess, or indeed treatment with a variety of retinoids, can potentially have disastrous effects on the developing fetus.
First, 5HT is a morphogen in the developing mammalian central nervous system; perturbations of this system lead to errors in the architectural assembly of the brain (Hamon et al.