A notable mention are the preventable causes of high DFT: medication (lidocaine, mexiletine, moricizine
, verapamil, venlafaxine, anesthetic agents--including propofol necessary for DFT testing, cocaine, sildenafil and amiodarone in chronic administration -acute i.v.
Rogers et al., "Mortality following ventricular arrhythmia suppression by encainide, flecainide, and moricizine
after myocardial infarction: the original design concept of the cardiac arrhythmia suppression trial (CAST)," Journal of the American Medical Association, vol.
Cardiovascular drugs, such as the type 1A anti-arrhythmics (quinidine [Quinaglute[R]], procainamide [Pronestyl[R]], disopyramide [Norpace[R]], and moricizine
[Ethmozine[R]]), digoxin (Lanoxin[R]), and diuretics demonstrated a higher risk for falls than any other cardiovascular drugs (Keller & Slattum, 2003; van der Velde, Stricker, Pols, & van der Cammen, 2006).
Both Cardiac Arrhythmia Suppression Trials (CAST I: encainide and flecainide; CAST II: moricizine
) showed that suppressing frequent PVCs significantly increased mortality in the treatment groups.
Effects of encainide, flecainide, imipramine and moricizine
on ventricular arrhythmias during the year after acute myocardial infarction: The CAPS.
Allowed medications included amiodarone, disopyramide, flecainide, moricizine
, procainamide, prop afenone, quinidine, sotalol, and a combination of these drugs.
2 to warn their patients to stop taking moricizine, made by Du Pont Pharmaceuticals in Wilmington, Del.
During the study, each volunteer took one of three daily doses of moricizine or placebo pills.
Known generically as moricizine, the drug was one of three that underwent CAST tests.
Craig Pratt of Baylor College of Medicine in Houston says there were eight other drugs in the same class as moricizine but each of them reportedly cause greater adverse effects.
A third drug in the trial, moricizine
, so far shows no significant adverse or beneficial trends in comparison with placebo and will continue under investigation.