Mortality following ventricular arrhythmia suppression by encainide, flecainide, and moricizine
after myocardial infarction: the original design concept of the cardiac arrhythmia suppression trial (CAST)," Journal of the American Medical Association, vol.
Cardiovascular drugs, such as the type 1A anti-arrhythmics (quinidine [Quinaglute[R]], procainamide [Pronestyl[R]], disopyramide [Norpace[R]], and moricizine
[Ethmozine[R]]), digoxin (Lanoxin[R]), and diuretics demonstrated a higher risk for falls than any other cardiovascular drugs (Keller & Slattum, 2003; van der Velde, Stricker, Pols, & van der Cammen, 2006).
Effect of the antiarrhythmic agent moricizine
on survival after myocardial infarction.
Effects of encainide, flecainide, imipramine and moricizine
on ventricular arrhythmias during the year after acute myocardial infarction: The CAPS.
Allowed medications included amiodarone, disopyramide, flecainide, moricizine
, procainamide, prop afenone, quinidine, sotalol, and a combination of these drugs.
2 to warn their patients to stop taking moricizine, made by Du Pont Pharmaceuticals in Wilmington, Del.
During the study, each volunteer took one of three daily doses of moricizine or placebo pills.
On July 30 of this year -- 18 months into the trial -- a review of the data revealed a disturbing trend:97 people in the moricizine group had died, compared with 74 in the placebo group.
Known generically as moricizine, the drug was one of three that underwent CAST tests.
Craig Pratt of Baylor College of Medicine in Houston says there were eight other drugs in the same class as moricizine but each of them reportedly cause greater adverse effects.
has yet to gain FDA approval and is not available for general use.