With the approval of
monotherapy for partial-onset seizures, Fycompa can now be prescribed to all patients with partial-onset seizures 12 years of age and older in the United States.
In patients who took the drug as
monotherapy, LMTX was associated with dose-dependent, statistically significant improvements in the Alzheimer's Disease Assessment Scale measures of cognition (ADAS-cog) and Alzheimer's Disease Cooperative Study Activities of Daily Living inventory (ADCS-ADL).
Patients were grouped according to whether they took the study drug as add-on therapy (85%) or as
monotherapy (15%).
The approval of glycopyrrolate/formoterol fumarate 9 mcg/4.8 meg is based on the PINNACLE trials, which demonstrated the product achieved improvement in morning predose forced expiratory volume in 1 second at 24 weeks (P less than .001), compared with its
monotherapy components and placebo, according to AstraZeneca's statement.
Only the first three, however, have an indication for use as
monotherapy. Despite this, convincing and validated randomized clinical trial (RCT) data demonstrated that the combination of TNFi plus a DMARD (usually MTX) is typically superior to either alone, and that there is no statistical difference when comparing TNFi to MTX when used in
monotherapy.
Combining an angiotensin converting enzyme inhibitor (ACE-I) with a thiazide, [beta]-blocker, or calcium channel blocker produces side effects similar to
monotherapy, as does combining an angiotensin receptor blocker (ARB) with a thiazide or calcium channel blocker (SOR: A, meta-analyses).
* Group A--Low dose mastic gum
monotherapy: 350 mg three times daily for 14 days;
This is compared to 44 percent of patients who achieved remission with infliximab
monotherapy and 30 percent with azathioprine alone.
The approval of Erbitux
monotherapy to shrink tumors in patients with metastatic disease who no longer respond to other forms of treatment is also important.
The only significant drug/defect associations occurred in women taking high doses of valproate, either as
monotherapy or polytherapy.
As a result, they were virtually being treated with protease-inhibitor
monotherapy. It also became evident that these drugs came with their own set of side effects.
Clarithromycin has been administered successfully as
monotherapy, and our case confirms these data.