monotherapy

(mŏn′ō-thĕr′ə-pē)

n. pl. monothera·pies

1. The treatment of a medical disorder with a single drug.

2. A type or instance of such treatment: evaluating antimalarial monotherapies.

monotherapy

Single drug therapy or treatment Therapeutics The management of a particular condition–eg, HTN, with a single agent. See Hypertension. Cf Polypharmacy.

References in periodicals archive ?

With the approval of monotherapy for partial-onset seizures, Fycompa can now be prescribed to all patients with partial-onset seizures 12 years of age and older in the United States.

U.S. FDA Approves Additional Use of Antiepileptic Drug Fycompa as Monotherapy for Partial-Onset Seizures

In patients who took the drug as monotherapy, LMTX was associated with dose-dependent, statistically significant improvements in the Alzheimer's Disease Assessment Scale measures of cognition (ADAS-cog) and Alzheimer's Disease Cooperative Study Activities of Daily Living inventory (ADCS-ADL).

Alzheimer's anti-tau drug fails, may show hint of effect

Patients were grouped according to whether they took the study drug as add-on therapy (85%) or as monotherapy (15%).

Anti-tau drug fails to slow atrophy, may preserve brain mass

The approval of glycopyrrolate/formoterol fumarate 9 mcg/4.8 meg is based on the PINNACLE trials, which demonstrated the product achieved improvement in morning predose forced expiratory volume in 1 second at 24 weeks (P less than .001), compared with its monotherapy components and placebo, according to AstraZeneca's statement.

Glycopyrrolate/formoterol combo gets nod for COPD

Only the first three, however, have an indication for use as monotherapy. Despite this, convincing and validated randomized clinical trial (RCT) data demonstrated that the combination of TNFi plus a DMARD (usually MTX) is typically superior to either alone, and that there is no statistical difference when comparing TNFi to MTX when used in monotherapy.

Monotherapy in rheumatoid arthritis

Combining an angiotensin converting enzyme inhibitor (ACE-I) with a thiazide, [beta]-blocker, or calcium channel blocker produces side effects similar to monotherapy, as does combining an angiotensin receptor blocker (ARB) with a thiazide or calcium channel blocker (SOR: A, meta-analyses).

Q/which combination drug therapies are most effective for hypertension?

* Group A--Low dose mastic gum monotherapy: 350 mg three times daily for 14 days;

Bactericidal action of mastic gum on H. pylori

This is compared to 44 percent of patients who achieved remission with infliximab monotherapy and 30 percent with azathioprine alone.

2-drug combo effective for Crohn's disease remission

The approval of Erbitux monotherapy to shrink tumors in patients with metastatic disease who no longer respond to other forms of treatment is also important.

FDA approves first head and neck cancer treatment in 45 years

The only significant drug/defect associations occurred in women taking high doses of valproate, either as monotherapy or polytherapy.

Drops in use of valproate linked to fewer Australian birth defects

As a result, they were virtually being treated with protease-inhibitor monotherapy. It also became evident that these drugs came with their own set of side effects.

Therapeutic and diagnostic advances in the HAART era

Clarithromycin has been administered successfully as monotherapy, and our case confirms these data.