obuense contains genes involved in antimicrobial resistance, such as marA, aminoglycoside-resistance protein kinase, p-lactamases, and monooxygenases
, which confer M.
PBO inhibits cytochrome P450 monooxygenases
and the use of PBO as synergized with pyrethroids recommended by WHO (2006) in cold and thermal fog formulations.
In their study, UMass Amherst researchers tested their hypothesis that once present, colon cancer was increased by enzymes known as cytochrome P450 (CYP) monooxygenases
and the fatty acid metabolites they form, epoxyoctadecenoic acids (EpOMEs).
The enzymes such as monooxygenases
, hydroxylases and dehydrogenases play a major role in formation of cresol intermediates and further, direct to Tri-carboxylic acid cycle (TCA).
CYP450 enzymes are monooxygenases
functionally related to other oxygenases, such as monoamine oxygenase and the lipoxygenase family [23, 24].
Recently, LPMOs (lytic polysaccharide monooxygenases
) have been suggested to make the cellulose polymer more accessible to the action of traditional cellulases through an oxidative mechanism .
Cytochrome P450 Monooxygenases
. Cytochromes P450 (P450s) are heme-containing monooxygenases
and widely present in species across the biological kingdoms.
Sorlie et al., "Structural and functional characterization of a conserved pair of bacterial cellulose-oxidizing lytic polysaccharide monooxygenases
," Proceedings of the National Acadamy of Sciences of the United States ofAmerica, vol.
Cytochrome P450 (CYP450) and flavin-containing monooxygenases
(FMOs) are the most important enzymes of phase 1 reactions.
Epoxyeicosatrienoic acids (EETs) are arachidonic acid derived metabolites generated by a family of cytochrome P450 (CYP) monooxygenases
and epoxygenases [4, 5].
The complete enzymatic hydrolysis of chitin to free GlcNAc involves lytic polysaccharide monooxygenases
(3) and glycoside hydrolases [EC.126.96.36.199]; the latter are classified by amino acid sequence homology into families 18, 19 and 20.