De Montellano, Bioactivation of Antituberculosis Thioamide and Thiourea Prodrugs by Bacterial and Mammalian Flavin Monooxygenases
Effect of some heavy metal salts on hepatic monooxygenases
after subchronic exposure.
It remains to be demonstrated experimentally, but given the difference in chemical structure, it is unlikely the CYP4 P450 monooxygenases
associated with imidacloprid exposure in D.
A preview of titles includes: regulation of alternative splicing through coupling with transcription and chromatin structure; nuclear-ADP-Ribosylation and its role in chromatic plasticity, cell differentiation, and epigenetics; the biology of proteostasis in aging and disease; PIWI-interacting RNA: its biogenesis and functions; structure, dynamics, assembly, and evolution of protein complexes; gating mechanisms of voltage-gated proton channels; form follows function: the importance of endoplasmic reticulum shape; cellulose degradation by polysaccharide monooxygenases
The over-expression of P450 monooxygenases
in pyrethroid-resistant insects and their possible role in enhanced metabolic detoxification of pyrethroid insecticides is well documented (Rodpradit et al.
As described above, all enzymes involved belong to a family of hemecontaining monooxygenases
(25) (or mixed-function oxidases (24)) called cytochrome P450 except 3[beta]-hydroxysteroid dehydrogenase/isomerase.
Several chapters focus on specific techniques, including use of cytochrome P450 monooxygenases
, ionic liquids & supercritical CO2, thiamine-based enzymes, and Baeyer-Villiger monooxygenases
Cytochrome P450 monooxygenases
belong to protein super family of diverse and widely distributed enzymes, which are mainly involved in metabolism of endogenous and exogenous compounds of structurally diverse nature (Hudgson, 1985; Nelson, 1987).
42] Most of these genes are monooxygenases
and glutathione s-transferases.
Some include xenobiotic detoxifying enzymes such as the cytochrome P-450 monooxygenases
, glutathione-S-transferases, and esterases (French-Constant et al.
The mechanisms of those compounds to inhibit chemically induced cancer have been shown to involve an increase in expression of glutathione transferases and quinone reductase and/or inhibition of cytochrome P450-dependent monooxygenases
(Brady et al.
BD is metabolized in the liver through oxidation by the family of cytochrome P450 monooxygenases
, a pathway that forms several epoxides, specifically l,2-epoxy-3-butene, 1,2,3,4-diepoxybutane, and 3,4-epoxy-l,2-butanediol (Filser et al.