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excess of monocytes in the blood; frequently used alone to refer to infectious mononucleosis.
cytomegalovirus mononucleosis a syndrome similar to infectious mononucleosis but caused by infection with cytomegalovirus.
infectious mononucleosis an acute infectious disease that causes changes in the leukocytes; it is caused by the Epstein-Barr virus and is usually transmitted by direct oral contact (which is why it is sometimes called the “kissing disease”). It occurs more frequently in the spring and affects primarily children and young adults. Although epidemics have been reported, some authorities doubt that the disorder has been the same in all instances. Called also glandular fever.
Symptoms. Generally, after an incubation period of one week to several weeks, headache, sore throat, fatigue, severe weakness, and influenzalike symptoms occur. Skin rashes may also occur. Diagnosis can be confirmed by the finding of a marked increase in the number of monocytes in the patient's blood. Besides these normal cells of the lymphocyte class, there is often an increase in atypical lymphocytes. Another diagnostic test that indicates mononucleosis is the paul-bunnell test, which demonstrates the presence of certain antibodies capable of causing clumping of cells in a sample of sheep's blood.

In about 8 to 10 per cent of all cases, the liver is involved and jaundice occurs, resulting in a condition that resembles infectious hepatitis. In rare cases, the heart, lungs, and central nervous system may also be affected. The spleen may become enlarged; one of the complications, serious but rare, is rupture of the spleen. The lymph nodes and spleen may both remain enlarged for sometime after other symptoms have disappeared.
Treatment. Treatment is chiefly symptomatic. Rest is especially important in the early stages of the disease, or later if the liver is involved. There is as yet no specific treatment for mononucleosis, and no immunization is available. Headache and sore throat may be relieved by aspirin and gargles. Although the more obvious symptoms may disappear after a period of rest, sufficient rest and curtailed activities must be maintained in order to improve the patient's severely weakened condition and prevent recurrence. There is often mental as well as physical fatigue, especially among students, and in these cases some mental depression may accompany convalescence.

Chronic, lingering infectious mononucleosis occurs in some patients. They experience profound fatigue, low-grade fever, swollen lymph glands, a sore throat, and aching muscles and joints. These symptoms can persist for months or years, and often cause the patient to be labeled neurotic because of a lack of objective evidence of disease. The condition can be definitively diagnosed by blood testing for antibodies to the Epstein-Barr virus. Unfortunately, diagnosis can provide psychological relief only, as there is no effective treatment or cure for the disorder.


Presence of abnormally large numbers of mononuclear leukocytes in the circulating blood, especially with reference to forms that are not normal.


/mono·nu·cle·o·sis/ (-noo″kle-o´sis) excess of mononuclear leukocytes (monocytes) in the blood.
chronic mononucleosis  chronic fatigue syndrome.
cytomegalovirus mononucleosis  an infectious disease caused by a cytomegalovirus and resembling infectious mononucleosis.
infectious mononucleosis  an acute infectious disease caused by the Epstein-Barr virus; symptoms include fever, malaise, sore throat, lymphadenopathy, atypical lymphocytes (resembling monocytes) in the peripheral blood, and various immune reactions.


(mŏn′ō-no͞o′klē-ō′sĭs, -nyo͞o-)
1. The presence of an abnormally large number of white blood cells with single nuclei in the bloodstream.
2. Infectious mononucleosis.

mononucleosis (mono)

Etymology: Gk, monos, single; L, nucleus, nut kernel; Gk, osis, condition
an abnormal increase in the number of mononuclear leukocytes in the blood. See also infectious mononucleosis.


See Infectious mononucleosis.


Presence of abnormally large numbers of mononuclear leukocytes in the circulating blood, especially with reference to forms that are not normal.


Any condition featuring an abnormal number of monocytes in the blood. See also GLANDULAR FEVER (infectious mononucleosis).


An infectious disease with symptoms that include severe fatigue, fever, sore throat, and swollen lymph nodes in the neck and armpits. Also called "mono."

mononucleosis (mˑ·nō·nōō·klē·ōˈ·sis),

n an infectious disease caused by the Epstein-Barr virus and characterized by a proliferation of white blood cells (specifically mononu-clear leukocytes). Symptoms include fatigue, aches, fever and chills, sore throat, swollen lymph nodes, and an enlarged spleen. Often occurs in adolescents. Also called
Epstein-Barr virus, EBV, glandular fever, or
infectious mononucleosis.


excess of mononuclear leukocytes (monocytes) in the blood.

Patient discussion about mononucleosis

Q. What is the connection between fibromyalgia and glandular fever? How can you protect yourself from this viral infection?

A. There is a notion that some of the autoimmune conditions are caused by a trigger in the shape of a virus. Like the papiloma virus and cervical cancer. So there might be a connection between fibromyalgia and a virus.

Q. can mono kill you if it gets to the liver? otherwise known as the kissing desiaes.

A. It can be fatal, not necessarily through infecting the liver but through rupture of enlarged spleen or obstruction of the throat, or through the development of cancer (e.g. lymphoma) later in life.

However, these complications are very rare, and most people recover from the disease without major complications.

You can read more here:

More discussions about mononucleosis
References in periodicals archive ?
Include infectious mononucleosis in the differential for patients presenting with vaginal ulcers--especially those who deny sexual activity.
However, based on the clinical syndrome of fever, exudative pharyngitis, and lymphocytosis, accompanied by positive EBV serology results, the diagnosis of a severe form of EBV infectious mononucleosis complicated by icteric hepatitis, skin vasculitis, and acalculous cholecystitis was considered.
Ebstein-Barr Virus infections, mononucleosis in children, I and II.
General Description of Leukocytes in Infectious Mononucleosis
A Prospective Clinical Study of Epstein-Barr Virus and Host Interactions during Acute Infectious Mononucleosis.
Hepatic function in mononucleosis induced by Epstein Barr virus and cytomegalovirus.
A 15-year-old boy was admitted with a 7-day history of severe tonsillitis secondary to infectious mononucleosis.
Aunque existen una serie de enfermedades parecidas a la mononucleosis, cuando la gente dice que tiene 'mononucleosis,' generalmente se refiere a la infeccion producida por el virus de Epstein-Barr (VEB).
Serology is not always necessary when clinical signs and symptoms are strongly suggestive of EBV mononucleosis, Dr.
Con la finalidad de valorar las caracteristicas clinicas y parametros hematologicos en pacientes con fiebre dengue y mononucleosis infecciosa, se evaluo un grupo de 25 y 18 pacientes, respectivamente, con edades comprendidas entre 12 y 40 anos que asistieron al ambulatorio "Arquimedes Fuentes Serrano" de la ciudad de Cumana, estado Sucre, en el periodo de febrero a octubre del ano 2003.
68), exposure to the Epstein-Barr virus in early life produces only flu-like symptoms but exposure at adolescence or later often results in mononucleosis, which is a possible precursor of multiple sclerosis, diabetes, rheumatoid arthritis, and chronic fatigue syndrome.