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mon·o·i·o·do·ty·ro·sine (MIT),

An intermediate in thyroid hormone synthesis.
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Thyroglobulin contains 140 tyrosine residues and serves as the matrix to which reactive iodine is attached to form monoiodotyrosine (MIT) and diiodotyrosine (DIT).
The tyrosines are iodinated at one (monoiodotyrosine) or two (diiodotyrosine) sites and then coupled to form the active thyroid hormones, tetraiodothyronine or thryoxine ([T.sub.4]) and triiodothyronine ([T.sub.3]).
HPLC analysis of carboxypeptidase-digested iodination products revealed that they all contained a monoiodotyrosine on the C terminus and at least one other labeled tyrosine.