who observed that LDL(-) promotes monocyte chemotactic protein 1 (MCP1) and interleukin 8 (IL8) release in human umbilical vein endothelial cells (HUVEC) .
Benitez et al., "Electronegative LDL from normolipemic subjects induces IL-8 and monocyte chemotactic protein secretion by human endothelial cells," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
These mediators included TNF-[alpha], fibroblast growth factor (FGF) 9, interferon (IFN) [gamma], IFN-[gamma]-inducible protein (IP) 10, RANTES, IL-17A, IL-12p70, IL-11, IL-10, IL-7, IL-6, IL-1[alpha], lymphotactin, oncostatin-M (OSM), growth-regulated [alpha] protein (KC/GRO), stem cell factor (SCF), macrophage inflammatory protein (MIP)-1[beta], MIP-2, tissue inhibitor of metalloproteinase (TIMP)-1, vascular endothelial growth factor (VEGF)-A, monocyte chemotactic protein
(MCP)-1, MCP-3, and MCP-5.
Many of the genes in this cluster had a functional association with the processes of inflammation and fibrosis including a) cd14, a monocyte marker and receptor controlling the release of inflammatory cytokines; b) Scya (small inducible cytokine subfamily) genes that are monocyte chemotactic proteins
; and c) Gp49b, a leukocyte immunoglobulin-like receptor.
Opdenakker, "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins
(MCP-2 and MCP-3) belonging to the chemokine family," Journal of Experimental Medicine, vol.