monocyte chemoattractant protein-1

Also found in: Acronyms.

mon·o·cyte che·mo·at·trac·tant pro·tein-1 (MCP-1),

secreted by endothelial cells of a blood vessel wall; it induces extravasation of monocytes.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Saitoh, "Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy," Journal of Clinical Laboratory Analysis, vol.
Radinahamed et al., "Urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratio as biomarkers for interstitial fibrosis and tubular atrophy in primary glomerulonephritis," Kidney and Blood Pressure Research, vol.
Lattuada et al., "Association between plasma monocyte chemoattractant protein-1 concentration and cardiovascular disease mortality in middle-aged diabetic and nondiabetic individuals," Diabetes Care, vol.
Kolattukudy, "Site-directed mutagenesis of monocyte chemoattractant protein-1 identifies two regions of the polypeptide essential for biological activity," The Biochemical Journal, vol.
Westwick, "Chemokine Gene-Expression and Secretion by Cytokine-Activated Human Microvascular Endothelial-Cells - Differential Regulation of Monocyte Chemoattractant Protein-1 and Interleukin-8 in Response to Interferon-Gamma," American Journal of Pathology, vol.
The monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C chemokine family.
Royo et al., "Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors," Journal of Neuroscience Research, vol.
Also, an unfavorable immune status appeared to be inversely proportional to the values of monocyte chemoattractant protein-1 MCP-1, while leptin values were not correlated with CD4 cell count or virologic status, but rather with HDL-cholesterol and waist circumference.
Dissocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficacy than specific antibodies for identification of clissocyanate asthma.
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in inflammation by regulating the recruitment of monocytes into tissues and their subsequent differentiation to macrophages [16].
Yin, "Expression of monocyte chemoattractant protein-1 in the cerebral artery after experimental subarachnoid hemorrhage," Brain Research, vol.
Becker, "Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis," Cerebrovascular Diseases, vol.

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