monoclonal immunoglobulin

(redirected from monoclonal protein)

mon·o·clo·nal im·mu·no·glob·u·lin

a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type.
Synonym(s): M protein (2) , monoclonal protein, paraprotein (2)

monoclonal immunoglobulin

M spike, M spot, myeloma component, myeloma protein A protein produced by clonally expanded immunoglobulin-producing cells seen in various malignancies–eg, myeloma, Waldenström's disease, CLL, and other lymphoproliferative disorders; MI production may occur in other malignancies–eg, bladder, cervix, liver CAs, angiosarcoma, KS Nonmalignant monoclonal conditions Infections–eg,.Acanthocheilonema perstans, Endolimax nana, Entamoeba hartmanni, filariasis, schistosomiasis, septicemia, syphilis, trichuriasis, TB, viral hepatitis, hematologic disorders–eg, anemia, autoimmune hemolytic anemia, hereditary spherocytosis, thalassemia, autoimmune disease–eg, glomerulonephritis, pemphigus vulgaris, scleroderma, liver disease, kidney disease, amyloidosis, acute porphyria, chronic salpingitis, systemic capillary leak syndrome, Gaucher's disease, uterine fibromas, cerebrovascular disease, ASHD. See Hybridoma.

mon·o·clo·nal im·mu·no·glob·u·lin

(mon'ō-klōn'ăl im'yū-nō-glob'yū-lin)
A homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells that; during electrophoresis of serum, appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass, and light chains of a single type.
Synonym(s): paraprotein (2) .
References in periodicals archive ?
In MGUS, the blood's plasma cells produce an abnormal protein called monoclonal protein that can be detected with blood tests.
MGUS still requires the presence of a serum monoclonal protein in a concentration of 3 g/dL or less, less than 10% plasmacytosis in the bone marrow, asymptomatic status, and absence of end-organ damage as traditionally defined in the acronym CRAB (calcium elevation, renal insufficiency, anemia, or bony disease).
How does your laboratory routinely quantitate monoclonal protein? Perpendicular drop of M-spike only (including area 521 77.3 below the spike) Tangent skimming of M-spike only (not including 61 9.1 underlying polyclonal immunoglobulin) Quantitative Ig class (nephelometry or turbidimetry) 42 6.2 Serum free light-chain ratio 13 1.9 Heavy/light chains (nephelometry or turbidimetry) 9 1.3 Other 28 4.2 Total 674 Quantitation not performed (a) 65 NA D.
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder,that occurs in 3% of the population aged more than 50 years, and is the commonest among plasma cell dyscrasias.1,2 The hallmark of Monoclonal gammopathies is the expansion of a single clone of plasma cells, which yields a homogeneous monoclonal protein (M-protein/M-component or paraprotein).
Taken together with the patient's lack of symptoms, the low (<1.0 g/dL) concentration of the monoclonal protein and a normal ratio of free [kappa] to free [lambda] light chains, the IgG [kappa] finding suggested a diagnosis of monoclonal gammopathy of undetermined significance.
Although Schnitzler syndrome requires the presence of monoclonal gammopathy to establish the diagnosis, the significance of the type of monoclonal protein is unclear.
Moreover, serum protein electrophoresis did not show any monoclonal protein spike.
We anticipated that treatment of the LPL and reduction of the monoclonal protein would also treat the von Willebrand syndrome, confirming that it was secondary to the monoclonal gammopathy and LPL.
Immunoglobulin D multiple myeloma is considered a rare subtype of myeloma, accounting for less than 2% of all myelomas, associated with an increased frequency of undetectable or small monoclonal protein levels in electrophoresis.
1 - Delivery of reagents with the lease system for electrophoretic separation and detection of monoclonal protein by immunofixation.
While the primary objective of the initial study is to evaluate safety and tolerability, the effect of SNS01-T on tumor response will also be evaluated using multiple well-established criteria including measurement of the monoclonal protein (M-protein).
Serum protein electrophoresis revealed 1.2 gm/dL of a monoclonal protein. Serum immunoelectrophoresis demonstrated an IgG lambda monoclonal protein.

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