monoclonal immunoglobulin


Also found in: Acronyms.

mon·o·clo·nal im·mu·no·glob·u·lin

a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type.
Synonym(s): M protein (2) , monoclonal protein, paraprotein (2)

monoclonal immunoglobulin

M spike, M spot, myeloma component, myeloma protein A protein produced by clonally expanded immunoglobulin-producing cells seen in various malignancies–eg, myeloma, Waldenström's disease, CLL, and other lymphoproliferative disorders; MI production may occur in other malignancies–eg, bladder, cervix, liver CAs, angiosarcoma, KS Nonmalignant monoclonal conditions Infections–eg,.Acanthocheilonema perstans, Endolimax nana, Entamoeba hartmanni, filariasis, schistosomiasis, septicemia, syphilis, trichuriasis, TB, viral hepatitis, hematologic disorders–eg, anemia, autoimmune hemolytic anemia, hereditary spherocytosis, thalassemia, autoimmune disease–eg, glomerulonephritis, pemphigus vulgaris, scleroderma, liver disease, kidney disease, amyloidosis, acute porphyria, chronic salpingitis, systemic capillary leak syndrome, Gaucher's disease, uterine fibromas, cerebrovascular disease, ASHD. See Hybridoma.

mon·o·clo·nal im·mu·no·glob·u·lin

(mon'ō-klōn'ăl im'yū-nō-glob'yū-lin)
A homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells that; during electrophoresis of serum, appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass, and light chains of a single type.
Synonym(s): paraprotein (2) .
References in periodicals archive ?
Suzuki et al., "An IgA1-lambda-type monoclonal immunoglobulin deposition disease associated with membranous features in a patient with chronic hepatitis C viral infection and rectal cancer," Clinical and Experimental Nephrology, vol.
PR corresponds to serum monoclonal immunoglobulin decreased by 50%, urinary monoclonal immunoglobulin decreased by 90%, and free light chains decreased by 50%.
* The amount of abnormal monoclonal immunoglobulin in the blood and urine.
If amyloid subtyping is performed, it should reveal monoclonal immunoglobulin light chains.
Glomerular disease with monoclonal immunoglobulin deposition is divided into two categories by electron microscopy, those with organized deposits and those with disorganized deposits [6].
There are no official guidelines for the optimal approach to screening patients for the presence of an abnormal monoclonal immunoglobulin, but a consensus has developed that a combination of tests is probably needed (3).
A sampling of topics in the following chapters: infection-related glomerulonephritis; discover of genes related to diabetic nephropathy in various animal models; glomerular basement membrane disorders in experimental models; lupus nephritis; monoclonal immunoglobulin light and heavy chain deposition diseases; HIV-associated nephropathy; some contrarian evidence in renal vasculature in essential hypertension; and glomerular repair--present status and future expectations.
In extramedullary plasmacytoma, immunohistochemical staining of tissue biopsies shows monoclonal immunoglobulin. Congo red stain is often positive for amyloid as a result of free light-chain deposition in soft tissue.
ABP 980 is being developed as a biosimilar to trastuzumab, a recombinant DNA-derived humanised monoclonal immunoglobulin G1 kappa antibody approved for the same cancers mentioned above.
Monoclonal immunoglobulin deposition disease (MIDD) is a rare disease characterized by the deposition of monoclonal immunoglobulin molecules in renal glomerular and tubular basement membranes.
The presence of a monoclonal immunoglobulin (2220 mg/dL) falsely increased the direct, but not the total, bilirubin measurement.

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