monoclonal immunoglobulin

mon·o·clo·nal im·mu·no·glob·u·lin

a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type.
Synonym(s): M protein (2) , monoclonal protein, paraprotein (2)

monoclonal immunoglobulin

M spike, M spot, myeloma component, myeloma protein A protein produced by clonally expanded immunoglobulin-producing cells seen in various malignancies–eg, myeloma, Waldenström's disease, CLL, and other lymphoproliferative disorders; MI production may occur in other malignancies–eg, bladder, cervix, liver CAs, angiosarcoma, KS Nonmalignant monoclonal conditions Infections–eg,.Acanthocheilonema perstans, Endolimax nana, Entamoeba hartmanni, filariasis, schistosomiasis, septicemia, syphilis, trichuriasis, TB, viral hepatitis, hematologic disorders–eg, anemia, autoimmune hemolytic anemia, hereditary spherocytosis, thalassemia, autoimmune disease–eg, glomerulonephritis, pemphigus vulgaris, scleroderma, liver disease, kidney disease, amyloidosis, acute porphyria, chronic salpingitis, systemic capillary leak syndrome, Gaucher's disease, uterine fibromas, cerebrovascular disease, ASHD. See Hybridoma.

mon·o·clo·nal im·mu·no·glob·u·lin

(mon'ō-klōn'ăl im'yū-nō-glob'yū-lin)
A homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells that; during electrophoresis of serum, appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass, and light chains of a single type.
Synonym(s): paraprotein (2) .
References in periodicals archive ?
Multiple myeloma is a hematologic malignancy characterized by proliferation of a neoplastic plasma cell population leading to increased production of a monoclonal immunoglobulin.
Serum protein electrophoresis, typically represented by a densitometry tracing of the pattern, should demonstrate a monoclonal immunoglobulin that is visualized as a peak (M-spike) in the [gamma]-globulin region (Figure 1, A).
Although all of the methods described above have been analogous to current clinical assays, both groups have also worked in parallel on disease-specific immunoglobulin quantification using peptides from the variable region of the monoclonal immunoglobulin secreted by MM tumor cells (6, 9).
Immunofixation electrophoresis revealed no monoclonal immunoglobulin bands.
WM is also called lymphoplasmacytic lymphoma because it occurs when abnormal lymphoplasmacytic cells multiply out of control, producing large amounts of a protein called monoclonal immunoglobulin M.
Yet, these tests are not quantitative in the strictest sense; they require skilled interpretation and cannot assess immune suppression of polyclonal immunoglobulins of the same isotype as the monoclonal immunoglobulin.
To link any renal alterations with an underlying plasma cell dyscrasia, there is a need to demonstrate the association of the particular lesion detected with deposition of monoclonal immunoglobulin components and to establish a cause-effect relationship.
Malignant plasma cells produce an abnormal protein called monoclonal immunoglobulin.
2] Additional immunostaining that revealed positivity for CD20 and light chain [Kappa] and demonstration of monoclonal immunoglobulin heavy chain gene rearrangement helped us to establish the diagnosis of lymphoma with certainty.
Monoclonal immunoglobulin light and heavy chain deposition diseases: molecular models of common renal diseases.
Overestimation of nephelometric measured intact monoclonal immunoglobulins could be explained by monoclonal immunoglobulin polymerization and by the differences in the immunoreactivity of monoclonal vs polyclonal immunoglobulins.

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