monoclonal gammopathy of undetermined significance


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monoclonal gammopathy of undetermined significance

a paraproteinemia (an abnormal gammaglobulin, typically with λ light chain component) of less than 3 g/100 mL, which, at the time of discovery, is without apparent cause; specifically, there is no evidence of multiple myeloma or other malignant disorders.

monoclonal gammopathy of undetermined significance

Benign monoclonal gammopathy, MGUS Hematology A condition defined by lab criteria Criteria Normal Hb, serum albumin < 20 g/L–US: < 2 g/dl, an M-component, no Bence-Jones proteinuria, < 5% plasma cells in the BM, no osteolytic lesions; MGUS differs from myeloma in that the plasma cells in the BM are < 20%, and the ESR and monoclonal component are lower Prognosis 20-40% of MGUS progress to malignant monoclonality Management Plasma exchange may be improve the neuropathy associated with IgA or IgG MGUS

monoclonal gammopathy of undetermined significance

A condition featuring the presence of a monoclonal protein in people with no evidence, for a period of years, of clinical indications of multiple myeloma or other related disorders. In a proportion of cases, however, a malignant plasma cell disease develops.

Monoclonal gammopathy of undetermined significance (MGUS)

Common condition in which M-protein is present, but there are no tumors or other symptoms of disease.
Mentioned in: Multiple Myeloma

Patient discussion about monoclonal gammopathy of undetermined significance

Q. Does anyone know anything about MGUS?

A. MGUS is a condition that affects a type of white blood cell known as a plasma cell. Plasma cells are a type of white blood cell that produce special proteins, known as antibodies or immunoglobulins. These antibodies circulate in the blood, ready to attack any viruses and bacteria that may be present in the body.
When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. All the antibodies are identical.

More discussions about monoclonal gammopathy of undetermined significance
References in periodicals archive ?
Table 3: Association between different risk factors and the prevalence of monoclonal gammopathy of undetermined significance
The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network.
Buadi, "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence," Mayo Clinic Proceedings, vol.
Fanconi's syndrome and distal (type 1) renal tubular acidosis in a patient with primary Sjogren's syndrome with monoclonal gammopathy of undetermined significance. Clin Nephrol 2006; 65:427-432.
A symptomless blood disorder, monoclonal gammopathy of undetermined significance (MGUS), is not linked to as many serious diseases as previously thought, according to a study published in the August 2009 issue of Mayo Clinic Proceedings.
In this patient, two separate entities were present simultaneously--an extramedullary IgA-secreting plasmacytoma and a monoclonal gammopathy of undetermined significance that had occurred as a result of the immunosuppression therapy for his rheumatoid arthritis.
* Nearly half, 46%, were unaware of blood tests they could order for monoclonal gammopathy of undetermined significance or myelodysplastic syndrome.
Monoclonal gammopathy of undetermined significance: natural history in 241 patients.
In humans, Potter says, plasma cell cancer appears infrequently The most common manifestation of a human plasma cell proliferation is monoclonal gammopathy of undetermined significance (MGUS), which produces benign tumors.
A 61-year-old female with a past medical history of presumed type 2 von Willebrand disease (vWD) diagnosed at age of 51 and IgM-kappa monoclonal gammopathy of undetermined significance (MGUS) diagnosed one year later presented to the hematology clinic with increasing frequency and severity of epistaxis.
Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study.
MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance. Blood.

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