monoclonal gammopathy of undetermined significance


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monoclonal gammopathy of undetermined significance

a paraproteinemia (an abnormal gammaglobulin, typically with λ light chain component) of less than 3 g/100 mL, which, at the time of discovery, is without apparent cause; specifically, there is no evidence of multiple myeloma or other malignant disorders.

monoclonal gammopathy of undetermined significance

Benign monoclonal gammopathy, MGUS Hematology A condition defined by lab criteria Criteria Normal Hb, serum albumin < 20 g/L–US: < 2 g/dl, an M-component, no Bence-Jones proteinuria, < 5% plasma cells in the BM, no osteolytic lesions; MGUS differs from myeloma in that the plasma cells in the BM are < 20%, and the ESR and monoclonal component are lower Prognosis 20-40% of MGUS progress to malignant monoclonality Management Plasma exchange may be improve the neuropathy associated with IgA or IgG MGUS

monoclonal gammopathy of undetermined significance

A condition featuring the presence of a monoclonal protein in people with no evidence, for a period of years, of clinical indications of multiple myeloma or other related disorders. In a proportion of cases, however, a malignant plasma cell disease develops.

Monoclonal gammopathy of undetermined significance (MGUS)

Common condition in which M-protein is present, but there are no tumors or other symptoms of disease.
Mentioned in: Multiple Myeloma

Patient discussion about monoclonal gammopathy of undetermined significance

Q. Does anyone know anything about MGUS?

A. MGUS is a condition that affects a type of white blood cell known as a plasma cell. Plasma cells are a type of white blood cell that produce special proteins, known as antibodies or immunoglobulins. These antibodies circulate in the blood, ready to attack any viruses and bacteria that may be present in the body.
When an abnormally large amount of one particular antibody is produced, this is called monoclonal gammopathy. All the antibodies are identical.

More discussions about monoclonal gammopathy of undetermined significance
References in periodicals archive ?
Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study.
Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study.
A Monoclonal gammopathy of undetermined significance (MGUS) is the term used to denote the presence of a monoclonal protein (M-protein, myeloma protein, or paraprotein) in persons without evidence of plasma-cell myeloma, Waldenstrom macroglobulinemia, primary amyloidosis, or related disorders.
If both cell populations are part of the same clone they could represent marginal zone lymphoma or lymphoplasmacytic lymphoma, (9,10) whereas if they are separate clones, they may indicate a low-grade B-cell lymphoma and a concurrent plasma-cell neoplasm, such as monoclonal gammopathy of undetermined significance.
9,10) Free light chain assay is a more sensitive methodology, and it is also performed to monitor patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance.
In addition, these measures are commonly assessed in patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering MM (SMM) as indicators of progression.
Fluorescence in situ hybridization analysis of aneuploidization patterns in monoclonal gammopathy of undetermined significance versus multiple myeloma and plasma cell leukemia.
In contrast, a majority of patients with small M-protein spikes have monoclonal gammopathy of undetermined significance (MGUS).
Using 2008 World Health Organization diagnostic criteria for WM, there is diagnostic overlap among WM, IgM monoclonal gammopathy of undetermined significance, and smoldering WM.
A diagnosis of FLC monoclonal gammopathy of undetermined significance (MGUS) was made in a patient with a [kappa]/[lambda] ratio of 14.
Immunophenotyping by flow cytometry, serum protein immunoelectrophoresis, or even bone marrow biopsy are sometimes performed and periodically repeated to evaluate multiple myeloma, monoclonal gammopathy of undetermined significance, or lymphoma that may be associated with AOXGDs, especially NBX or rarely AAPOX.

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