monoclonal gammopathy


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mon·o·clo·nal gam·mop·a·thy

any one of a group of disorders due to proliferation of a single clone of lymphoid or plasma cells and characterized by the presence of monoclonal immunoglobulin in serum or urine (visible on electrophoresis as a single peak).

monoclonal gammopathy

A condition characterized by the clonal proliferation of immunoglobulin-producing B cells
Monoclonal gammopathy types
Malignant
Multiple myeloma
Variants of multiple myeoloma
• Solitary plasmacytoma of bone
• Extramedullary plasmacytoma
• Plasma cell leukemia
• Non-secretory myeloma
Lymphoproliferative disorders
• Waldenström's macroglobulinemia
• Lymphoma
Heavy chain disease (γ, α, μ)
Amyloidosis
Of undetermined significance
Benign (IgG, IgA, IgM, IgD, or light chains)
Associated neoplasms that rarely produce monoclonal proteins
Biclonal gammopathies  
References in periodicals archive ?
In April 2017, the International Kidney and Monoclonal Gammopathy Research Group (IKMG) redefined MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined hematological criteria for treatment of a specific malignancy (12).
The physiopathological significance of benign monoclonal gammopathy: A study of 64 cases.
In conclusion, we present the case of a patient with scleromyxedema without concomitant monoclonal gammopathy and draw attention to hydroxychloroquine treatment.
A majority of participant laboratories (66.6%; 499 of 749) kept a file on all known monoclonal gammopathy patients to assist in review (Table 6, question L).
Keywords: Monoclonal gammopathy of undetermined significance, Prevalence, Serum Protein Electrophoresis, Age increment, Erythrocyte sedimentation rate, Anemia.
Taken together with the patient's lack of symptoms, the low (<1.0 g/dL) concentration of the monoclonal protein and a normal ratio of free [kappa] to free [lambda] light chains, the IgG [kappa] finding suggested a diagnosis of monoclonal gammopathy of undetermined significance.
Benveniste, "Sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance," Current Opinion in Neurology, vol.
The electrophoresis and immunofixation revealed an IgM kappa monoclonal gammopathy. The rest of the blood work was negative.
Moreover, the clonal plasma cell process in POEMS usually does not reach the level of PCM (it usually is characterized as a monoclonal gammopathy of undetermined significance (MGUS)) [12], and EPO levels are usually decreased in POEMS [13].
We should suspect this entity in adult patients, usually older than 40, with a chronic urticarial rash associated with any of the following signs or symptoms: fever, fatigue, general malaise, arthralgia, enlarged liver, or spleen, enlarged lymph nodes, leukocytosis and/or increased markers of inflammation, monoclonal gammopathy and a neutrophilic infiltrate on skin biopsy (2).
The most common comorbidity was inflammatory bowel disease (IBD, 35%), followed by hidradenitis suppurativa (14%), rheumatoid arthritis (12%), monoclonal gammopathy (12%), leukemia (2%), and lymphoma (2%).
Plasma cell dyscrasias, characterized by the monoclonal growth of plasma cells, include multiple myeloma, Waldenstrom macroglobulinemia (WM), monoclonal gammopathy of undetermined significance (MGUS), and amyloidosis.

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