In April 2017, the International Kidney and Monoclonal Gammopathy
Research Group (IKMG) redefined MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined hematological criteria for treatment of a specific malignancy (12).
The physiopathological significance of benign monoclonal gammopathy
: A study of 64 cases.
In conclusion, we present the case of a patient with scleromyxedema without concomitant monoclonal gammopathy
and draw attention to hydroxychloroquine treatment.
A majority of participant laboratories (66.6%; 499 of 749) kept a file on all known monoclonal gammopathy
patients to assist in review (Table 6, question L).
Keywords: Monoclonal gammopathy
of undetermined significance, Prevalence, Serum Protein Electrophoresis, Age increment, Erythrocyte sedimentation rate, Anemia.
Taken together with the patient's lack of symptoms, the low (<1.0 g/dL) concentration of the monoclonal protein and a normal ratio of free [kappa] to free [lambda] light chains, the IgG [kappa] finding suggested a diagnosis of monoclonal gammopathy
of undetermined significance.
Benveniste, "Sporadic late-onset nemaline myopathy with monoclonal gammopathy
of undetermined significance," Current Opinion in Neurology, vol.
The electrophoresis and immunofixation revealed an IgM kappa monoclonal gammopathy
. The rest of the blood work was negative.
Moreover, the clonal plasma cell process in POEMS usually does not reach the level of PCM (it usually is characterized as a monoclonal gammopathy
of undetermined significance (MGUS)) , and EPO levels are usually decreased in POEMS .
We should suspect this entity in adult patients, usually older than 40, with a chronic urticarial rash associated with any of the following signs or symptoms: fever, fatigue, general malaise, arthralgia, enlarged liver, or spleen, enlarged lymph nodes, leukocytosis and/or increased markers of inflammation, monoclonal gammopathy
and a neutrophilic infiltrate on skin biopsy (2).
The most common comorbidity was inflammatory bowel disease (IBD, 35%), followed by hidradenitis suppurativa (14%), rheumatoid arthritis (12%), monoclonal gammopathy
(12%), leukemia (2%), and lymphoma (2%).
Plasma cell dyscrasias, characterized by the monoclonal growth of plasma cells, include multiple myeloma, Waldenstrom macroglobulinemia (WM), monoclonal gammopathy
of undetermined significance (MGUS), and amyloidosis.