monoclonal antibody therapy


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monoclonal antibody therapy

The use of monoclonal antibodies to suppress immune function, kill target cells, or treat specific inflammatory diseases. Because of their high level of specificity, they bind to precise cellular or molecular targets. A potential problem associated with the use of monoclonal antibodies is an allergic reaction to the foreign antigens in the antibody, since they are created from mouse cells. Monoclonal antibodies have numerous uses in health care. See: table; hybridoma; monoclonal antibody
Name of AntibodyCondition Treated or Prevented
AdalimumabRheumatoid arthritis; psoriasis
BevacizumabSolid tumors
EdrecolomabSolid tumors
EfalizumabPsoriasis
EnlimomabOrgan transplant rejection
IbritumomabFollicular lymphoma
InfliximabCrohn's disease; rheumatoid arthritis
NatalizumabRelapsing forms of multiple sclerosis
OmalizumabAllergic rhinitis
OKT3Organ transplant rejection
PalivizumabRespiratory syncytial virus
RituximabLeukemias and lymphomas
RhuMAb/VEGFSolid tumors
TositumomabB cell lymphoma
TranstuzumabMetastatic breast cancer
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
In mouse models, CS3002 combined with PD-1 monoclonal antibody therapy or endocrine therapy has shown improved tumor suppressing activities compared to monotherapies.
There have been a number of new medicines in the last few years which have revolutionised vets' ability to treat these cases including a monoclonal antibody therapy, the first of this type of drug to hit the veterinary market.
The company plans to submit an IND to the FDA by the end of 2018 to evaluate the safety and tolerability of multiple doses of FT516 in multiple dosing cycles in combination with FDA-approved monoclonal antibody therapy. A poster presentation at ASH highlighted new in vivo data demonstrating that FT596 displays long-term persistence without systemic cytokine support.
Merina Thomas, M.D., from the University of Michigan in Ann Arbor, and colleagues describe three patients who developed uveal effusion after initiation of anti-PD-1 and anti-PD-L1 monoclonal antibody therapy. The patients were two white men aged 52 and 85 years with metastatic cutaneous melanoma and a 68-year-old African-American man with metastatic adenocarcinoma of the lung.
Nexvet's pipeline product ranevetmab, a mAb targeting nerve-growth factor for treatment of chronic pain associated with osteoarthritis in dogs, would, upon approval, be the companion animal industry's first monoclonal antibody therapy administered monthly by injection for chronic pain.
Against the EGFR-targeted monoclonal antibody therapy, when applied across all treatment lines either as a single agent or in combination with chemotherapy, the mutation could indicate the therapy's non-responsiveness.
Filings: XBiotech has been granted Fast Track Designation for its novel True Human monoclonal antibody therapy intended to treat all forms of Staphylococcus aureus infections, including Methicillin-resistant S.
Aratana Therapeutics has a full license from USDA for its monoclonal antibody therapy called AT-004, intended for dogs with B-cell lymphoma.
(3), (4) In some recent reports, monoclonal antibody therapy, including anti-CD20 or anti-interleukin-6 (IL-6), has been used effectively in some cases.
Commonly applied biotherapeutic measures include monoclonal antibody therapy, radioimmunology therapy, active immunotherapy, adoptive immunotherapy, B-cell lymphoma-2-targeted therapy and specific micromolecular-targeted drug therapy.
Washington, September 2 ( ANI ): A monoclonal antibody therapy developed by MassBiologics of the University of Massachusetts Medical School (UMMS) and tested in an animal model at the Texas Biomedical Research Institute, prevents infection by the hepatitis C virus (HCV).

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