In mouse models, CS3002 combined with PD-1 monoclonal antibody therapy
or endocrine therapy has shown improved tumor suppressing activities compared to monotherapies.
There have been a number of new medicines in the last few years which have revolutionised vets' ability to treat these cases including a monoclonal antibody therapy
, the first of this type of drug to hit the veterinary market.
The company plans to submit an IND to the FDA by the end of 2018 to evaluate the safety and tolerability of multiple doses of FT516 in multiple dosing cycles in combination with FDA-approved monoclonal antibody therapy
. A poster presentation at ASH highlighted new in vivo data demonstrating that FT596 displays long-term persistence without systemic cytokine support.
Merina Thomas, M.D., from the University of Michigan in Ann Arbor, and colleagues describe three patients who developed uveal effusion after initiation of anti-PD-1 and anti-PD-L1 monoclonal antibody therapy
. The patients were two white men aged 52 and 85 years with metastatic cutaneous melanoma and a 68-year-old African-American man with metastatic adenocarcinoma of the lung.
Nexvet's pipeline product ranevetmab, a mAb targeting nerve-growth factor for treatment of chronic pain associated with osteoarthritis in dogs, would, upon approval, be the companion animal industry's first monoclonal antibody therapy
administered monthly by injection for chronic pain.
Against the EGFR-targeted monoclonal antibody therapy
, when applied across all treatment lines either as a single agent or in combination with chemotherapy, the mutation could indicate the therapy's non-responsiveness.
Filings: XBiotech has been granted Fast Track Designation for its novel True Human monoclonal antibody therapy
intended to treat all forms of Staphylococcus aureus infections, including Methicillin-resistant S.
Aratana Therapeutics has a full license from USDA for its monoclonal antibody therapy
called AT-004, intended for dogs with B-cell lymphoma.
(3), (4) In some recent reports, monoclonal antibody therapy
, including anti-CD20 or anti-interleukin-6 (IL-6), has been used effectively in some cases.
Commonly applied biotherapeutic measures include monoclonal antibody therapy
, radioimmunology therapy, active immunotherapy, adoptive immunotherapy, B-cell lymphoma-2-targeted therapy and specific micromolecular-targeted drug therapy.
Washington, September 2 ( ANI ): A monoclonal antibody therapy
developed by MassBiologics of the University of Massachusetts Medical School (UMMS) and tested in an animal model at the Texas Biomedical Research Institute, prevents infection by the hepatitis C virus (HCV).