monocarboxylate transporters

monocarboxylate transporters

transmembrane carrier molecules, co-transporting monocarboxylic acid anions (typically lactate) and protons (H+) through cell membranes, notably those of skeletal and cardiac muscle fibres. Considered to be responsible for the major part of lactate transport at low concentrations but, as saturation of the carrier approaches, simple diffusion (which is primarily of the undissociated lactic acid) becomes more important. See also lactate, lactic acid.
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They found that CAFs can remove lactate from the tumor environment and utilize it as an energy source by increased activity of monocarboxylate transporters.