In mammals, mononuclear phagocytes differentiate in bone marrow from stem cells- monoblasts
, promonocytes and monocytes.
Blasts refer to myeloblasts, lymphoblasts, monoblasts
, promonocytes, and megakaryoblasts.
Bone marrow aspiration detected 85% monoblasts
. Morphologic, cytochemical, and immunocytochemical studies confirmed the diagnosis of AML (M5A-FAB).
In general, the cells of diffuse large B-cell lymphoma have thick nuclear membranes and basophilic nucleoli, unlike myeloblasts or monoblasts
, which have thin nuclear membranes and pinpoint nucleoli.
Hematologic parameters in the patients at AML diagnosis Case 1 Case 2 Case 3 Hb (g/dl) 6.0 7.30 5.40 Hct (%) 23.7 - 16.80 WBC/[mm.sup.3] 20,700 7,000 29,900 Platelet/[mm.sup.3] 12,000 21,000 52,000 Blasts Blood smear 44% 18% 60% Bone marrow 77% 33% 62% monoblasts
Auer rods(+) myeloblasts Cytochemical features MPO(+) MPO(+) MPO(+) NSE(+) D.
and promonocytes are included in the blast count as blast equivalents, while monocytes are excluded.