monoaminoxidase

monoaminoxidase

an enzyme that inactivates NORADRENALINE by oxidation in ADRENERGIC nerves.
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These include 5-[HT.sub.1A] and 5-[HT.sub.2A] receptors, 5-HT transporters, DA [D.sub.1] and [D.sub.2] receptors, DA transporters, [alpha]1 and [alpha]2 adrenoceptors, monoaminoxidase (MAO) A, [GABA.sub.A] and [GABA.sub.B] receptors, GABA transaminase, glutamatergic N-methyl-D-aspartate (NMDA), and [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, as well as voltage-regulated sodium and calcium channels [13, 14].
The ECT, NADPH oxidase, monoaminoxidase, [p66.sup.shc], [alpha]-glycerophosphate dehydrogenase, electron transfer flavoprotein (ETF) and ETF dehydrogenase, and aconitase may also contribute to the production of ROS in mitochondria [8].
The action of serotonin (5-hydroxytryptamine 5-HT) in the synapse is terminated by monoaminoxidase enzyme activity and neuronal uptake pump for 5-HT which allows reuse of the 5-HT molecules in the presynaptic neuron.
Legenda: TGI, trato gastrintestinal; DP, Doenca de Parkinson; MAO, monoaminoxidase; COMT, catecol-O-metiltransferase; D1, D2 e D3, receptores dopaminergicos; ID, inibidor da dopadescarboxilase; AD, agonista dopaminergico.
Desde a decada de 1950, com a descoberta da acao terapeutica dos antidepressivos triciclicos (ADTs) e dos inibidores da monoaminoxidase (IMAOs), diversos grupos de farmacos foram acrescentados ao arsenal terapeutico, tais como os inibidores seletivos da recaptacao da serotonina (ISRSs), os inibidores da recaptacao de serotonina e noradrenalina (IRSNs), o antagonista noradrenergico e serotoninergico especifico (mirtazapina), os antagonistas 5-HT2, a bupropiona e, mais recentemente, a agomelatina (Sena, 2009).
In general, monoaminoxidase inhibitors (MAOi), tricycles or SSRIs may induce suppression on reproductive axis (LABBATE et al., 1998; PERRY; FULLER, 1997; TORRES et al., 1998).
In this there are biological causes (higher testosterone levels, lower levels of monoaminoxidase and cortical immaturity during puberty and adolescence in males) and socio-cultural determinants (gender role regardless of alexithymia, or difficulty to verbally identify and express emotions) (Moral, 2010a).
Para o controle farmacologico da depressao sao disponibilizados os Antidepressivos Triciclicos (ATCs) tendo como exemplo a imipramina, doxepina, protriptilina e amitriptilina; Antidepressivos de Segunda Geracao (ASG) exemplificados pela amoxapina, maprotilina, trazodona e a bupropiona; Antidepressivos de Terceira geracao (ATG) como a mirtazapina, venlafaxina, nefazodona, duloxetina; Inibidores Seletivos da Recaptacao de Serotonina (ISRS) que incluem a fluoxetina, paroxetina, sertralina, fluvoxamina e o citalopram; os Inibidores da Monoaminoxidase (IMAO) que sao representados pela fenelzina, isocarboxazida e a tranilcipromina (Katzung, 2010).
In these glands, monoaminoxidase, the enzyme that metabolizes 5-HT is also detected.
In addition, the drink contains a monoaminoxidase (MAO) inhibitor from the vine Banisteriopsis caapi.
Os antidepressivos triciclicos, os inibidores da monoaminoxidase (IMAO) e os inibidores seletivos da recaptacao de serotonina (ISRS) foram os agentes avaliados.
In these glands, monoaminoxidase, the enzyme that metabolizes 5HT, is also detected (Aguilar et al., 1995; Campos et al., 1990; Ellis et al., 1972; Tinajero et al., 1993; Sanders-Bush & Mayer, 2001; Verbeuren, 1989).