Depression is classified as a neurochemical disorder and has long been considered a mood disorder in which stress plays a vital role via an impaired monoaminergic
neurotransmitter, usually serotonin (5-HT) [104-106].
Aboul-Fotouh, "Behavioral effects of nicotinic antagonist mecamylamine in a rat model of depression: prefrontal cortex level of BDNF protein and monoaminergic
neurotransmitters," Psychopharmacology, vol.
Depression and poor sleep: the effect of monoaminergic
antidepressants in a pre-clinical model in rats.
Ascorbic acid administration produces antidepressant-like effect: evidence for the involvement of monoaminergic
(9,14,20) They have ascending projections to the cerebral cortex, as well as descending projections to all of the monoaminergic
and cholinergic cell groups of the arousal systems.
Similarly, analgesics with monoaminergic
properties induce an antidepressant effect (Rojas-Corrales et al.
Even so, many strategies remain focused on directly targeting monoaminergic
circuits because this mechanism of action is compelling and understandable.
In addition, this study also examined the effects of MST on the levels of monoaminergic
neurotransmitters (NE, DA and 5-HT), together with AChE activity in the brain tissues of aged mice, all of which are known to be important to mediation of learning and memory processes.
It has been suggested that the epileptogenic effects of tricyclic antidepressants are a consequence of enhanced monoaminergic
Cortisol in violent suicidal behaviour: association with personality and monoaminergic
Considering that the monoaminergic
systems are the prevalent targets affected in the pathophysiology and treatment of human depression (Holsboer, 2004), the present study aimed to correlate the antidepressant-like activity of the plant extracts with changes in the central monoaminergic
A comparative study of monoaminergic
involvement in the antinociceptive action of E-2078 morphine and U-50488E.