monoamine hypothesis

monoamine hypothesis

the classical theory of the neurochemical basis of depression linking it to a deficiency of at least one of three monoamine neurotransmitters: norepinephrine, serotonin, or dopamine.

mon·o·am·ine hy·po·the·sis

(mon'ō-ă-mēn' hī-poth'ĕ-sis)
The classical theory of the neurochemical basis of depression linking it to a deficiency of at least one of three monoamine neurotransmitters, norepinephrine, serotonin, or dopamine.
References in periodicals archive ?
Importantly, the monoamine hypothesis was cited in conjunction with medication referral in two-thirds of medication responses (67.4%, n = 29).
The monoamine hypothesis of depression, involving dysregulation of the serotonergic, noradrenergic and dopaminergic systems (neurotransmitter synthesis, storage and release, and receptor sensitivity) was hypothesised to be the primary cause of depression for over 50 years.
The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation.
The monoamine hypothesis says that exercise increases the availability of monoamines such as serotonin, epinephrine, and dopamine.
The relationship between depression and asthma has been explained using two hypotheses- the monoamine hypothesis and the cholinergic hypothesis.
One of the most valid theories of the etiology of depression was thus formulated, namely the monoamine hypothesis, which involved the deficit of cathecolamines at the synaptic cleft as an underlying mechanism in depression.
The original monoamine hypothesis of depression was based on serendipitous discoveries.
The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis. J Hist Neurosci.
The monoamine hypothesis of depression postulates that symptoms originate from underactivity of monoamines, such as serotonin, norepinephrine, and dopamine, in the brain.
The monoamine hypothesis of depression predicts that the underlying pathophysiological basis of depression is, at least in part, a depletion in the levels of 5-HT, NE, and/or DA in the CNS.
The development, nearly 50 years ago, of the monoamine hypothesis of depression has been a driving force behind research and drug development in the decades since.