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Glycerol with an acyl moiety esterified to position 1 (that is, 1-monoacylglycerol) or position 2 (that is, 2-monoacylglycerol); an intermediate in the degradation and synthesis of lipids; 2-monoacylglycerols are a major end product of triacylglycerol degradation.
Synonym(s): monoglyceride
References in periodicals archive ?
Importantly, the research team discovered that an enzyme called alpha/beta hydrolase domain-6 (in short ABHD6) breaks down monoacylglycerol and thus negatively controls insulin release.
Solvent optimization for efficient enzymatic monoacylglycerol production based on a glycerolysis reaction.
Monoacylglycerol synthesis via enzymatic glycerolysis using a simple and efficient reaction system.
Efforts are focusing on 60% fat spreads, with a control or standard spread containing commercial soft margarine and distilled monoacylglycerols to serve as a reference for comparing the dairy-based spreads.
Overall, as compared to LF-ctrl mice, our study suggests that the combined effects of TCDD and HFD are a) to increase the uptake of FA (Cd36), b) to normalize FA [beta]-oxidation (Cpt1a), c) to decrease de novo lipogenesis (Acaca, Fasn, Scd1) and carbohydrate metabolism (Glut2, Pklr), d) to decrease de novo triglyceride synthesis (Dgat2/1) while increasing the monoacylglycerol pathway (Mogat1) and e) to decrease very low-density lipoprotein secretion (Mttp).
2007) Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus.
It is well known that lipase is produced mainly in the pancreas and it is thought to play a relatively minor role in lipid digestion in fishes, and catalyses the breakdown of triacylglycerol first to diacylglycerol and then to monoacylglycerol (Zambonino-Infante and Cahu, 2001; Kolkovski,2001).
Washington, November 2 ( ANI ): A new study has identified an enzyme called Monoacylglycerol lipase (MAGL) as a potential therapeutic target to treat or prevent Alzheimer's disease.
The cannabinoid syndrome from OPs involves inhibition of monoacylglycerol lipase and fatty acid amide hydrolase, elevated levels of the endocannabinoids (2-arachidonoyl glycerol and anandamide), and reduced amounts of arachidonic acid (Nomura and Casida 2011) (see Supplemental Material, Figure 10C), but the relevance to wildlife is unknown.
Experts at The Scripps Research Institute identified the enzyme, called monoacylglycerol lipase (MAGL) as a key player responsible for the aggressive behaviour of cancer cells.
During digestion, the pancreatic lipase action specifically removes fatty acids at the 1,3 position while the resulting monoacylglycerol molecule is efficiently incorporated into micelles (Lien, 1994), leading to preferential absorption of fatty acids at the 2 position of the glycerol backbone of triacylglycerols.