Drugs that produce increased serotonin neurotransmission, such as serotonin re-uptake inhibitors, monamine
oxidase inhibitors, or tramadol, if administered concurrently, may produce a life-threatening "serotonin syndrome," composed of altered cognition, neuromuscular activity, and autonomic function (86).
Serotonin (hydroxytryptamine, or 5-HT) is a monamine
neurotransmitter that enhances relaxation and smooth/controlled motor coordination (by inhibiting quick motor responses).
The second type was the monamine
oxidase (MAO) inhibitors (phenelzine-Nardil; isocarboxazid-Marplan; tranycypromine-Parnate and others).
John's wort with anesthesia may be unfounded due to the fact that the herb has no in vivo monamine
oxidase (MAO) inhibitor activity.
Some medications from which to choose include N-methyl-D-aspartate (NMDA) inhibitors, monamine
oxidase-B inhibitors, and acetylcholine-enhancing agents.
Tricyclic antidepressants (TCAs) were used infrequently, while monamine
oxidase inhibitors (MAOIs) and electroconvulsive therapy were not prescribed at all during the 12-month study period.