monacolin

monacolin

(mŏn″ŭ-kŏl′ĭn)
One of a class of chemicals that reduce high cholesterol levels. Monacolin K is marketed as an alternative medicine called “red yeast rice extract” and as the proprietary medication lovastatin.
References in periodicals archive ?
The FDA's previous decision that red yeast rice is an acceptable dietary supplement with naturally occurring levels of Monacolin K may set precedent for full spectrum or broad spectrum hemp extract that contains cannabidiol, or CBD, Piper Jaffray analyst Michael Lavery tells investors in a research note.
The authors of this study measured the monacolin K content of 28 brands of red yeast rice supplements purchased from mainstream US retailers.
Marked variability of monacolin levels in commercial red yeast products buyer beware!
In a recent study, a second nutraceutical product that contains 200 mg BBR, 3mg monacolin K, 10 mg chitosan, and 10 mg [CoQ.sub.10] once a day for 12 weeks reduced LDL-C by 19% and non-HDL-C by 15% [37].
According to research published online June 23, 2017 in the European Journal of Preventive Cardiology, manufacturers of red yeast rice supplements have failed to adhere to FDA directives that call for standard concentrations of the active ingredient, monacolin K, in these supplements.
RYR contains chemicals that are similar to prescription statin medications including monacolin K (the same structure as the drug lovastatin).
The most studied combination of lipid lowering-nutraceuticals is a property product containing a red yeast rice extract with 3 mg monacolin K and berberine 500 mg per daily dose (Armolipid Plus[R]).
Several studies have demonstrated that the bioactive components present in red-koji include monacolin K, [gamma]-aminobutyric acid (Gaba), and dimerumic acid, which are thought to possess anti- hypercholesterolemic, anti-inflammatory, and antioxidant properties, and may help in the treatment of hypotension (Aniya et al., 2000; Su, Wang, Lin, & Pan, 2003).
Monacolin K of red rice (10 mg, 90% by policosanol) is able to inhibit the HMG-CoA reductase, which is a key enzyme in the biosynthesis of cholesterol.
It contains a wide range of biologically active compounds, including lovastatin (monacolin K).
The dietary supplement Red Yeast Rice has been advanced as a natural alternative for lowering cholesterol, as it contains ingredients such as monacolin K that may stop the production of HMG-CoA reductase (Kalaivani et al.