molecular replacement


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molecular replacement

A method of analysing biomacromolecular structures based on related, previously solved molecular structures.
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Chymosin is many times larger than any molecule whose structure had previously been determined without the use of isomorphous replacement, molecular replacement or anomalous dispersion, and the map demonstrates the potential of maximum-entropy methods in macromolecular structure determination.
To the extent that these two damage-repair processes (recombinational repair of nuclear DNA, and molecular replacement of cytoplasmic DNA) fail during gametogenesis, the metabolic functions of some germ cells will be compromised, and there will be gametic deaths.
Combining image-based assays with powerful molecular replacement technology for structure-function studies, we will 1) determine the contribution of branched and non-branched actin filament populations to contractile ring formation; 2) explore its ultra-structural organization in collaboration with a world expert in electron microcopy; 3) investigate how the contractile ring network is dynamically remodeled during constriction with the help of a novel laser microsurgery assay that has uncovered a remarkably robust ring repair mechanism; and 4) use a targeted RNAi screen and phenotype profiling to identify new components of actomyosin contractile networks.

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