molecular replacement


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molecular replacement

A method of analysing biomacromolecular structures based on related, previously solved molecular structures.
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Chymosin is many times larger than any molecule whose structure had previously been determined without the use of isomorphous replacement, molecular replacement or anomalous dispersion, and the map demonstrates the potential of maximum-entropy methods in macromolecular structure determination.
To the extent that these two damage-repair processes (recombinational repair of nuclear DNA, and molecular replacement of cytoplasmic DNA) fail during gametogenesis, the metabolic functions of some germ cells will be compromised, and there will be gametic deaths.
The nematode s versatile genetic tools, its biochemical tractability, and the powerful molecular replacement technologies available, this makes for a uniquely attractive experimental system to address the mechanisms employed by dynein regulators through a combination of biochemical, proteomic, and cell biological assays.

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