molecular hybridization


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hybridization

 [hi″brid-ĭ-za´shun]
1. the production of hybrids.
fluorescent in situ hybridization (FISH) a genetic mapping technique using fluorescent tags for analysis of chromosomal aberrations and genetic abnormalities. Called also chromosome painting.
molecular hybridization in molecular biology, formation of a partially or wholly complementary nucleic acid duplex by association of single strands, usually between DNA and RNA strands or previously unassociated DNA strands, but also between RNA strands; used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands.
References in periodicals archive ?
The detection mechanism involves molecular hybridization: a substrate is coated with a monoclonal antibody; as the solution to be tested (the analyte) flows though the device any protein molecules compatible or complimentary to the detector molecules will bind to them, resulting in an electrical or optical signal.

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