molecular histology
molecular histology
The study of the functional molecules within tissues, using techniques such as immunocytochemistry or in situ hybridization.
References in periodicals archive
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Extending the applications envelope of MALDI TOF/TOF beyond the conventional concepts of what's possible in molecular histology, glycoprotein and biopharmaceutical analysis, Bruker introduced the newest member in its Flex series of MALDI TOF/TOF mass spectrometers, the autoflex speed, at Pittcon 2014.
This method simplifies targeted tissue analysis for tissue proteomic mapping compared to molecular histology (3) or proteohistography (4).
Bruker's market leading, top of the range product has been significantly enhanced to offer both increased analytical power and entirely new functionality, extending the applications envelope of MALDI TOF/TOF far beyond the conventional concepts of what's possible in molecular histology, glycoprotein and biopharmaceuticals analysis.
While biomarker discovery in large tissue-sample cohorts can now be achieved at record high speed, Bruker has also significantly extended the discovery potential of Molecular Histology with the new ImageID[TM] workflow.
In addition, as recently announced, the integration of the Carl Zeiss' MIRAX Virtual Slide Scanner has enabled revolutionary advances in non-targeted molecular histology with high spatial resolution (research use only).
Carl Zeiss' MIRAX Virtual Slide Scanner and Bruker's MALDI Molecular Imager(TM) now enable non-targeted molecular histology with high spatial resolution in an integrated solution (research use only) for biological tissue research and clinical pathology research.
Integration of MIRAX Virtual Slide Scanner from Carl Zeiss into Bruker's MALDI Molecular Imager[TM] Enables Non-Targeted Molecular Histology -- Combined Solution to be Introduced at German Pathology Society (DGP) Meeting in June 2009
The goal of the Bruker-Carl Zeiss collaboration is to advance molecular histology research by providing an integrated solution (for research use only) for biological tissue research and pathology that adds non-targeted molecular information and 'molecular contrast' to histology.
from tumors) can be generated and used for biomarker discovery and molecular histology.
The integration of Carl Zeiss' MIRAX Slide Scanner results into the MALDI Molecular Imager solution allows the direct overlay of the full microscopic image with the full molecular and spectral information in one convenient visualization software tool, enabling true untargeted molecular histology.
The complete Bruker solution comprises the new ImagePrep[TM] device for automated high-resolution matrix application on tissue, the unique SmartBeam[TM] laser technology and the proprietary ClassImaging[TM] algorithm for tissue classification and biomarker detection, molecular histology as well as imaging of drug and metabolite distributions in drug development.
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