molecular disease


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molecular

 [mo-lek´u-ler]
of, pertaining to, or composed of molecules.
molecular disease any disease in which the pathogenesis can be traced to a single chemical substance, usually a protein, which is either abnormal in structure or present in reduced amounts.

mo·lec·u·lar dis·ease

a disease in which the manifestations are due to alterations in molecular structure and function.

molecular disease

Any condition caused by a defect in a gene encoding one or a few proteins–eg, sickle cell anemia, Gaucher disease. See Inborn errors of metabolism.

mo·lec·u·lar dis·ease

(mŏ-lekyū-lăr di-zēz)
A disease in which the manifestations are due to alterations in molecular structure and function.

mo·lec·u·lar dis·ease

(mŏ-lekyū-lăr di-zēz)
Disease with manifestations due to alterations in molecular structure and function.

Patient discussion about molecular disease

Q. what makes Arthritis a genetic disease?

A. First of all, the term arthritis is a bit inaccurate: Arthritis denotes an inflammation of joints. There are many kinds of arthritis that may result from different causes, and therefore, are different diseases: septic arthritis (inflammation due to infection of joint) has much less genetic background than ankylosing spondylitis (an arthritis of the lower back joints that occurs almost exclusively in people with certain genetic background).

The arthritis with the genetic background are usually the autoimmune ones: Due to genetic determinants, the immune system of some people is programmed to recognize the various parts of the joints (and other organs as well) as foreign (i.e. like bacteria) and thus launches an attack on them. In normal immune system, that doesn't happen.

You may read more here:
http://en.wikipedia.org/wiki/Autoimmune_disease

Q. Is bipolar disease a hereditary problem? My only son is in his teens that is the age to enjoy life, but he cannot enjoy his life with his friends because we found that he is suffering from a bipolar condition. I feel so sad for him and though my care-free days have gone, I often think about how much fun I had at his age. I too suffered from a bipolar disorder and my mom too. Is bipolar disease a hereditary problem? I want him to help to enjoy his life.

A. I agree with you. No one should suffer because of hereditary problems. This is the same situation here as genes are passed from generation to generation. This information is inconclusive because many who may have had bipolar disorders did not have it checked out. Who is to say, how many people 50 years ago had it but dismissed it as being moody, or ill tempered. Doctors were not aware about this problem years ago. Some time back, someone who showed signs of a mental disorder was straight away shoved into a mental hospital and left to suffer. Besides they are often treated with electric shock therapy eventually getting out of control. Testing is still in progress to find out if genetics play a role but these theories may take several more years before they can have a better understanding.
http://www.youtube.com/watch?v=f7uKg7ujoig&eurl=http://www.imedix.com/health_community/vf7uKg7ujoig_film_mental_illness_released_strive_happiness?q=bipolar%20disease%&feature=player_embedded

Q. Is FMS heredetery? My mother was diagnosed with FMS and I would like to know what are the chances I’ll have it too.

A. Hereditary is not the right term. It’s not a genetic disease but The cause of fibromyalgia remains elusive. However, recent studies show that genetic factors can predispose individuals to a genetic susceptibility to fibromyalgia.

More discussions about molecular disease
References in periodicals archive ?
These disease commons form a network (figure 5) that will exploit the significant economies of scale and opportunities for cross learning (for example, common pathways and drugs) that come from rethinking cancer as a molecular disease.
Designation as a "molecular disease" was first applied by what scientist to the disorder arising from a change in a single amino acid residue in the beta chain of the human Hbg molecule?
Pauling and other leading figures continued to view certain human abnormalities (including mental deficiency) as "molecular diseases" which might be "cured" through a better understanding of DNA structure and function.
Today, as an assistant professor in Columbia University's division of autoimmune and molecular diseases, Dr.
Since the discovery of the causative mutation of sickle cell anemia, hemoglobinopathies have become the iconic molecular diseases, with some 900 mutations reported to date (http://globin.cse.psu.edu).

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