molecular chaperone

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Related to molecular chaperone: Chaperone molecule

molecular chaperone

A protein that shapes other protein molecules so they can work optimally as receptors or can be secreted or cleared from cells.

molecular chaperone

see CHAPERONE.

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References in periodicals archive ?

Optimisation of production of a domoic acid-binding scFv antibody fragment in Escherichia coli using molecular chaperones and functional immobilisation on a mesoporous silicate support.

Soluble Expression of Humanized Anti-CD20 Single Chain Antibody in Escherichia coli by Cytoplasmic Chaperones Co-expression

Molecular Chaperones Modulate a-Synuclein Aggregation and Toxicity.

Chaperone-Based Therapies for Disease Modification in Parkinson's Disease

Molecular chaperones are essential for the maintenance of cellular homeostasis by facilitating various functions including degradation of proteins [1], translocation [2], folding of co-translational products [3], and protein complex assembly [4].

Investigating the chaperone properties of a novel heat shock protein, Hsp70.c, from Trypanosoma brucei

Heat shock protein 70 (HSP70) are the molecular chaperones that assist in folding of newly synthesized polypeptides, refolding of misfolded proteins and translocation of proteins through biological membranes, and in addition have regulatory functions in signal transduction, cell cycle and apoptosis.

Heat shock and the heat shock proteins: an overview

Chaperonins form a sub-group of molecular chaperones and 10-kDa antigen has homology with the GroES or chaperonin-10 (Cpn l0) family of heat shock proteins (17-19).

Streptomycin induced protein expression analysis in Mycobacterium tuberculosis by two-dimensional gel electrophoresis & mass spectrometry

In addition to its functions as ER molecular chaperone and [Ca.sup.2+]-binding protein (Lee 2001), Grp78 has been suggested to suppress oxyradical accumulation and mitochondrial dysfunction (Yu et al.

Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells

Molecular chaperones, like their human counterparts, prevent inappropriate liaisons between their charges and tempters that would lead them astray.

How proteins take shape: guardians give a new twist to protein folding

Inhibitors of Molecular Chaperones as Therapeutic Agents

Hsp90 the molecular chaperone is capable of binding nuclear receptor and steroid hormone receptor as well as binding severalprotein kinases molecular (including tyrosine protein kinase and serine/threonine kinase in the signal transduction pathway) regulating their bioactivity and participating in a range of life processes such as mitosis immunity or signal transduction (Pearl and Prodromou 2000; Picard 2002; Pratt and Toft 2003; PACopyrightroval et al.

Gene Cloning and Gene Expression of Hsp90 from Meloidogyne incognita under the Temperature and Heavy Metal Stress

Then molecular chaperone appeared as an endogenous protein for proper folding and/or assembly of another protein or protein complex, (32) followed by chemical chaperone (33) and chaperone therapy.

Emerging novel concept of chaperone therapies for protein misfolding diseases

Ganetespib, an investigational drug candidate, is a selective inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone which controls the folding and activation of a number of client proteins that drive tumor development and progression, added the company.

Synta Pharmaceuticals Corp to start pan-European Study of ganetespib in p53 mutant, metastatic ovarian cancer patients

Molt cycle-dependent molecular chaperone and polyubiquitin gene expression in lobster.

Heat-shock response of the upper intertidal barnacle Balanus glandula: thermal stress and acclimation