molecular autopsy

molecular autopsy

A term of art for postmortem genetic testing in cases in which the cause of death is unascertained after a thorough autopsy. Molecular autopsies are especially important in sudden cardiac deaths, as a significant minority may be linked by genetic testing to inherited cardiac diseases, including arrhythmic disorders such as congenital long Q-T syndrome and Brugada syndrome, which can be appropriately managed if identified in vivo.
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Keeping this in mind, molecular autopsy should be considered as a part of medicolegal investigation in sudden cardiac deaths without structural alterations.
Nevertheless, the way forward in this country is to consider a thorough molecular autopsy in each case of unexplained death to determine the cause, including cardiological and genetic evaluation of the first- and second-degree relatives of the deceased.
Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: A molecular autopsy of 49 medical examiner/coroner's cases.
ese drew a blank as did biochemistry and Another doctor, Kay Metcalfe, a consultant clinical geneticist, arranged for a molecular autopsy to be carried out to try to 'nd out what had been happening in Dexter's heart.
This Illumina and UNTHSC partnership will focus on projects, including a range of forensically relevant genetic markers for human identity testing, pharmacogenetics for molecular autopsy, microbial forensics, and additional markers and methods to generate investigative leads in criminal cases and matters of national security.
The report, called "Pathogenesis of Unexplained Drowning: New Insights from a Molecular Autopsy," was published in the May edition of the Mayo Clinic Proceedings.
The projects outlined in the agreement include studies on a range of forensically relevant genetic markers for human identity testing, pharmacogenetics for molecular autopsy, microbial forensics, and additional markers and methods to generate investigative leads in criminal cases and matters of national security.
Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds.
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