References in periodicals archive ?
Glucose and water distribute freely between erythrocytes and plasma; therefore, the molality (but not the concentration) of glucose is identical in erythrocytes and plasma.
The molality results from the direct-reading sensor can be multiplied by a factor derived from the ratio of the water concentrations of calibrator and sample to yield the true glucose concentration.
The sensor detects molality, but the system reports results relative to the concentration (not molality) of glucose in the calibration solution.
This result is expected because the direct biosensor detects molality (amount of glucose per unit of water mass in the sample), which is identical in whole blood and its separated plasma.
The latest generation of direct-reading glucose biosensors measures molality of glucose (amount of glucose per kilogram of water) in undiluted plasma or whole blood.
Biosensors that require dilution before measurement will underestimate molality, because when whole blood is diluted, e.
Furthermore, a new quantity and reference interval based on molality would probably not be accepted in clinical practice.
We found that a standardized conversion was best, resulting in better agreement when molality was converted to glucose concentration for patients' samples.