Otuk, Synthesis and biological evaluation of some new thiosemicarbazide, 4-thiazolidinone, 1, 3, 4-oxadiazole and 1, 2, 4-triazole-3-thione derivatives bearing imidazole [1, 2-a]pyridine moiety
, Acta Pharm Turcica.
From the results obtained, it has been observed that the adhesive formulations with aromatic isocyanate adduct shows lesser gel time as compared to formulations with aliphatic or cycloaliphatic isocyanate moiety
Seven proton signals attached to oxygen bearing carbons assignable to a sugar moiety
were present at [[delta].sub.H] 4.82 (1H, d, J = 7.3 Hz), 3.72 (1H, dd, J = 5.01, 11.8 Hz), 3.26-3.30 (2H, br, m), 3.16 (2H, t, J = 9.1 Hz), and 3.75 (1H, dd, J = 1.8, 11.8 Hz).
Microemulgel an overwhelming approach to improve therapeutic action of drug moiety
. Saudi Pharm J.
Concomitant CT scan abdomen demonstrate duplex left kidney and double ureters with large solid enhancing mass at lower pole moiety
of left duplex kidney which is indenting and displacing lower pole moiety
pelvi-calyceal system without invading and upper pole moiety
pelvi-calyceal system of left duplex kidney was intact.
In this case, the upper pole moiety
of the right duplicated kidney was small and dysplastic and the ultrasound failed to demonstrate duplex renal collecting system.
pe HMBC spectrum revealed pat H-6 (A 3.84 d J=7.2 Hz) was related to pe carbonyl group (A 166.1) of a benzoyloxy moiety
while H-7 (A 4.1 dd J=7.2 Hz) to anoper carbonyl group of pe second benzoyloxy moiety
From the docking studies it was observed that strong interactions of oxygen atoms of the sulfate moiety
of the compound with both the nickels in the active site of the enzyme were established at a distance of 1.87 and 1.66 A, respectively.
The :HNMRspectrum of 4 shows signals at 0.28 and 1.04 ppm for methyl groups involved in the tert-butyldimethylsilane fragment; at 0.96 ppm for methyl group bound to steroid nucleus; and at 1.24-7.36 ppm for steroid moiety
. The [sup.13]C NMR spectrum of 4 contains peaks at -4.40 and 25.66 ppm for methyl groups involved in the tert-butyldimethylsilane fragment; at 13.45 ppm for methyl group bound to steroid nucleus; at 18.06 ppm for carbon bound to methyl groups involved in the tert-butyldimethylsilane fragment; at 21.70-153.30 ppm for steroid moiety
; and at 219.64 ppm for ketone group.
Hanmi's product would be the first non-innovator pharmaceutical product commercialized in the United States that contains the active moiety
Our approach to tackle this problem is to synthesize alternate substrates that lack the 3-oxo moiety
and purify wild-type and T140A mutant Esal enzymes using affinity chromatography.
The molecular weight of water-insoluble diblock copolymer was 6970 and contained 4% of TEMPO moiety
, while that of the corresponding random copolymers containing 6% of TEMPO moiety
was 4840 and soluble in water.