Tumor suppressive microRNA-133a regulates novel targets: moesin
contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.
E-Cadherin, zyxin, and moesin
were identified as genes differentially expressed in these clusters.
The protein kinase A-anchoring protein moesin
is bound to pigment granules in melanophores.
1); amino-terminus of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase gene (ATIC, 2q35); TRK-fused gene (TFG, 3q21), with 3 variants depending on the length (short, long, extra-long); clathrin heavy polypeptide gene (CLTC, 17q23); moesin
gene (MSN, Xq11-12); myosin heavy chain 9 gene (MYH9, 22q11.
The immunophenotype of basal-like tumors, as defined by GEP or by IHC surrogate markers, is characterized by positive expression of basal CKs, EGFR, p53, P-cadherin, caveolins 1 and 2, cyclin E, Ki-67, c-Kit, fascin, Sox2, moesin
, vimentin, nestin, and laminin (Figure 2).
Some actin assembly-regulating proteins (thymosins, moesin
, Arp 2/3) were also up-regulated, while muscle contractile proteins were either up-regulated ([alpha]-cardiac myosin heavy chain, atrial myosin light chain 1) or down-regulated (titin, tropomyosin 4, troponin I, etc).