Associated with this, AJs are disrupted in these cells, which is mediated by the inactivation of merlin, a member of the ezrin, radixin, and moesin
(ERM) family of proteins that links actin filaments to AJ complexes .
Tumor suppressive microRNA-133a regulates novel targets: moesin
contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.
The ezrin/radixin/moesin (ERM) family is composed of ezrin, radixin, and moesin
. These proteins act as linkers between the actin cytoskeleton and plasma membrane proteins and play important roles in cell adhesion, polarity, and migration .
Il se perfectionne ensuite aupres de maEtres prestigieux tels Manuel Rosenthal a Paris, Moesin
a Saint-Petersbourg et Daniel Barenboim a Berlin.
Another in vitro study found that kinetin, EGCG (a component found in green tea), all-trans-retinoic acid and selenium induced changes in the aging-related proteins moesin
, rho guanosine-5'-diphosphate-dissociation inhibitor, and actin, providing a possible mechanism for their role in preventing skin aging (16).
E-Cadherin, zyxin, and moesin
were identified as genes differentially expressed in these clusters.
It is most recently shown that I/R-induced Mst1 activation is mediated by neurofibromin 2 (NF2, Merlin), a 4.1, ezrin, radixin, moesin
(FERM) domain-containing protein responsible for membrane and actin cytoskeleton association .
TNF[alpha] promotes the expression of CD44, the principal transmembrane adhesion receptor for hyaluronic acid, and moesin
phosphorylation by protein kinase C (PKC), which leads to the pericellular interaction of hyaluronic acid and CD44.
Ezrin, also identical to cytovillin or villin 2, is a component of cell-surface structures belonging to the ezrin/radixin/ moesin
(ERM) protein family that acts as a membrane organizer and linker between the plasma membrane and cytoskeleton [10, 11].
The protein kinase A-anchoring protein moesin
is bound to pigment granules in melanophores.
(191-193) Other translocation partners include non-muscle tropomyosin (TPM3, 1q25 and TPM4, 19p13.1); amino-terminus of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase gene (ATIC, 2q35); TRK-fused gene (TFG, 3q21), with 3 variants depending on the length (short, long, extra-long); clathrin heavy polypeptide gene (CLTC, 17q23); moesin
gene (MSN, Xq11-12); myosin heavy chain 9 gene (MYH9, 22q11.2); and ALK lymphoma oligomerization partner on chromosome 17 (ALO17, 17q25).