The advent of positron emission tomography (PET) and more specifically, the improvement in the synthesis of selective radioligands has allowed researchers to investigate the physiological functioning of the endogenous modulatory
system, especially the dopaminergic and opioidergic systems, in vivo, and more important, to correlate the functioning of those systems to experimental acute pain and also to chronic pain syndromes.
We can make sense of these intricate modulations according to the model of modulatory
neurotags and their effect on action neurotags and competition among neurotags for influence; the odor activates a modulatory
neurotag, which in turn influences action neurotags (Fig.
In comparison with the R-VS condition, the modulatory
effect on the connection from the IPS to the PMv increased significantly in the R-TS condition (p < 0.01).
In this study, we investigated the modulatory
effect of Cynara scolymus LE on chemically-induced DNA damage and chromosomal mutations using CHO cells.
Finally, the multistability of this neuronal oscillator was regulated by modulatory
This study, looking at the protective and modulatory
effects of a sorghum diet, said that daily sorghum diets significantly reduced the high levels of sugar and fats, such as cholesterol, in the blood of diabetic animals.
However, low concentration (0.01 uM) of nicotine had no significant growth modulatory
effect compared with control.
"It turns out that low-frequency sounds have a clearly definable modulatory
influence on spontaneous otoacoustic emissions," says Drexl.
Finally, the neural correlates and stability over time of gratification delay are discussed and a new triple process model is proposed, adding a modulatory
insula-based network to the traditionally balanced amygdala/striatum and PFC-based behavioral systems.
SignaBlok is developing a new class of therapies - SCHOOL peptides, the innovative modulatory
peptides that can be rationally designed for nearly any cell surface receptor and have broad potential to treat and prevent a wide range of serious diseases with unmet clinical needs.
CLA is known for its anti-cancer and immune modulatory