The company's small molecule therapeutics are designed to selectively modulate
the cellular signals that are aberrant in disease processes caused by the dysregulation of mTORC1 activation to address a range of diseases, including neurological and fibrotic disorders, immunometabolism, and certain rare diseases.
Activation of an ERE-dependent luciferase reporter gene in both tadpole and fish indicates that waterborne estrogens can directly modulate
transcription of estrogen-responsive genes in the brain.
A recent study demonstrated that downregulation of AhR by siRNA inhibits functional interactions between dioxin and estrogen, and modulates
transition of MCF-7 breast cancer cells through the cell cycle (Abdelrahim et al.
The easiest way to generate GMSK is to modulate
a VCO with the incoming serial data stream scaled correctly in amplitude for a modulation index of 0.5 and Filtered by the Gaussian premodulation Filter.
* Genetic research to determine the prevalence of genetic polymorphisms of genes that modulate
response to endotoxin in diverse human populations
In spite of this species difference in PPAR expression, hypolipidemic fibrates have been shown to induce hypolipidemia in humans and to modulate
gene expression (e.g., genes regulating lipid homeostasis) in human hepatocytes by PPAR activation.
Voltage-dependent calcium channels are composed of four principal subunits: the transmembrane, pore-forming [Alpha]1 subunits and three accessory subunits that modulate
channel function--the glycosylated [Alpha]2[Delta] subunits, the integral membrane subunits, and the cytoplasmic [Beta] subunits.
The subcarrier is used to modulate
the RIC unit's antenna impedance.
To extend the application to transmission marking, the low frequency modulation signal is available to modulate
directly an AM transmission chain.