modifier gene


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Related to modifier gene: recessive epistasis, epistatic

mod·i·fi·er gene

a nonallelic gene that controls or changes the manifestation of a gene by interfering with its transcription.

modifier gene

any gene that alters the phenotypic expression of a nonallelic gene. see GENETIC BACKGROUND.
References in periodicals archive ?
Therefore, we attempted to understand whether human BOP gene might be a modifier gene for HCMP In this purpose, we analyzed all coding regions of human BOP gene both in the patients diagnosed with HCMP and in the healthy controls.
Thus, nuclear modifier genes or other modifier factors may modulate the phenotypic manifestation of the 12S rRNA gene mutations by interacting with the gene either suppressing/enhancing the effect of the mutation (75,98).
As we saw in Result 4, GE may evolve even if the modifier gene has no effect on the trait parameters.
A possible explanation for the difference in variance is the presence of at least one modifier gene.
The clinical variability observed in HCM disease, could be influenced by several factors, such as modifier genes, epigenetic factors, microRNAs, posttranslation protein modifications and environmental factors (1, 24, 25).
To explain the phenotypic variability within the presented family, it can be speculated that additional polymorphisms or modifier genes influenced the variable phenotype.
Sutcliffe's gene hunt offered up good matches, candidates, for each of the three disease modifier genes discovered by the Case Western scientists, and one of these candidates-the mouse gene corresponding to a gene known to predispose humans carrying particular variations of it to develop early-onset Alzheimer's disease-was of special interest to his team.
Through the research, the scientists will also be able to identify potential modifier genes and examine their relationship to cardiac structure and function in athletes of differing ethnicities and diseased individuals.
Background-specific modifier genes may be responsible for this.
The authors concluded that MyD88-dependent signaling controls the expression of several key modifier genes of intestinal tumorigenesis and has a critical role in spontaneous and carcinogen-induced tumor development.
cystic fibrosis), where we previously thought pathways were relatively straightforward, there are often complicating factors, such as modifier genes.