Therefore, we attempted to understand whether human BOP gene might be a modifier gene
for HCMP In this purpose, we analyzed all coding regions of human BOP gene both in the patients diagnosed with HCMP and in the healthy controls.
Thus, nuclear modifier genes
or other modifier factors may modulate the phenotypic manifestation of the 12S rRNA gene mutations by interacting with the gene either suppressing/enhancing the effect of the mutation (75,98).
It is noteworthy that evolution toward genes modifying the fitness cost (modifier genes
) of resistance esterase genes have not been observed in C.
As we saw in Result 4, GE may evolve even if the modifier gene
has no effect on the trait parameters.
Alternatively, if the [Ace.sup.R] gene is the same in the entire sampled area, its cost could be reduced if modifier genes
are present in Spain.
A possible explanation for the difference in variance is the presence of at least one modifier gene
. Examples of common bunt resistance modifier genes
producing small effects are known (Holton and Heald, 1941).
Screening SLC39A4 Interacting Partners Identified Rare Deleterious Variants in Candidate Modifier Genes
. The patient B03 suffered a particularly severe form of AE and therefore is a good candidate to identify additional deleterious genetic modifiers of AE.
Some factors such as a second hit and modifier genes
might underlie the variable expression of NF1 within the members of this family.[sup],
Axenfeld-Rieger syndrome is a rare autosomal dominant disorder where phenotypes of the same mutation are variable; this is likely to be caused by environmental factors and/or modifier genes
It involves dealing with three distinct genetic systems; the recessive mutant alleles of opaque and floury genes being the first, second being alleles of endosperm hardness modifier genes
(en- modifiers) and third being a distinct set of amino acid modifier genes
(aa-modifiers) (Krivanek et al., 2006).Therefore, knowledge about the nature of the gene action is essential for maize breeders enabling them to optimize their breeding programs better.
Combining their vast resources in PD and our capabilities in research and clinical development, we believe we can make important advances in understanding and ultimately discovering new treatment approaches for this devastating disease." The multiyear collaboration includes an array of PD-related activities designed to drive advances in basic science and treatment, including discovery of gene targets and modifier genes
that might serve as novel therapeutic targets; creation of well-defined, patient-derived induced pluripotent stem cells (iPSC); a study of gasbointestinal symptoms related to PD; a search for quantitative and symptom-based trial endpoints; and the potential identification of new therapeutic approval pathways.
The collaboration includes an array of PD-related activities designed to drive advances in basic science and treatment including, discovery of gene targets and modifier genes
that might serve as novel therapeutic targets; the creation of well-defined patient-derived induced pluripotent stem cells (iPSC); a study of gastrointestinal symptoms related to PD; a search for quantitative and symptom-based trial endpoints; as well as the potential identification of new therapeutic approval pathways.