Use of the Barthel index and modified rankin scale
in acute stroke trials.
Modified Rankin Scale
runs from 0-6, running from perfect health without symptoms to death14.
 demonstrated retrospectively from the Virtual International Stroke Trials Archive that aphasia at baseline and at 3 months and persistent dysarthria at 3 months were associated significantly with a poorly modified Rankin Scale
in a large cohort (n = 8,904).
Total Lower TSPO Higher TSPO ([less than or (>0.46 ng/ml) equal to] 0.46 ng/ml) Clinical worsening, 13 (34.2) 2 (10.5) 11 (57.9) n (%) mRS, mean (SD) 4.39 (1.22) 4.00 (1.1) 4.79 (1.2) mRS [greater than or 30 (78.95) 12 (63.2) 18 (94.7) equal to] 4, n (%) BI, mean (SD) 32.8 (35.1) 46.3 (36.1) 19.2 (28.9) BI [less than or 21 (55.2) 7 (36.8) 14 (73.7) equal to] 30, n (%) Death, n (%) 8 (20.05) 2 (10.5) 6 (31.5) P OR (95% CI) Clinical worsening, 0.001 11.69 (2.08-65.6) n (%) mRS, mean (SD) 0.02 mRS [greater than or 0.01 10.50 (1.14-96.57) equal to] 4, n (%) BI, mean (SD) 0.02 BI [less than or 0.02 4.80 (1.20-19.13) equal to] 30, n (%) Death, n (%) 0.23 3.92 (0.67-22.7) mRS, modified Rankin Scale
; BI, Barthal Index; OR, odds ratio; CI, confidence interval; SD, standard deviation.
By using exploratory logistic regression analysis adjusted for patient background characteristics, it was shown that the risk for certain combinations of secondary endpoints was lower in the CA group than in the A group [all vascular events and silent brain infarcts: odds ratio (OR) = 0.37, p = 0.04; stroke and silent brain infarcts: OR = 0.34, p = 0.04; all vascular events, worsening of modified Rankin Scale
scores and silent brain infracts: OR = 0.41, p = 0.03].
This implies that the stroke outcome at 7 days as measured by the Modified Rankin scale
is significantly associated with the level of serum albumin at stroke onset (Table 7).
However, the study found no significant difference for its primary endpoint: the percentage of patients with a modified Rankin Scale
score of 0-1 when measured 90 days after their respective strokes.
Efficacy outcomes involved the evaluation of Barthel Index (BI) and modified Rankin Scale
(mRS) at endpoint.
Disability measures in stroke: relationship among the BartheI Index, the FunctionaI Independence Measure, and the Modified Rankin Scale
Functional outcomes were evaluated by the modified Rankin Scale
(mRS) at the first follow-up clinic visits, which usually occurred 2 to 4 weeks after discharge from the hospital.
Poor neurological outcome (Modified Rankin Scale
score of 4-6) was the same in both groups (52% vs 52%, respectively) and was 54% in the hypothermia group and 52% in the control group when assessed by the Cerebral Performance Category of 3-5 (p=0.78).
In the ACE64 study, acute ischemic stroke patients with large vessel occlusions achieved high revascularization rates of 96 % Thrombolysis in Cerebral Infarction 2b/3, with complete revascularisation at 62% TICI 3, a fast procedure time of 35 minutes and modified Rankin Scale
<=2 at discharge of 46 %.