LineaRx seeks to commercialize the biotherapeutic value of Applied DNA's deep expertise and experience in the design, manufacture and chemical modification of DNA
by large scale polymerase chain reaction.
(NASDAQ: APDN), seeks to commercialise the biotherapeutic value of Applied DNA's deep expertise and experience in the design, manufacture and chemical modification of DNA
by large scale polymerase chain reaction (PCR).
Leveraging Applied DNA's expertise in large-scale PCR-based production and chemical modification of DNA
, LineaRx will utilize its non-viral, plasmid-free platform to develop and produce expression vectors for CAR T therapies, including its own anti-CD19 CAR T therapy candidate, LinCART19.
Chemical modification of DNA
bases, 5-methylcytosine, plays a key role in epigenetic gene regulation (Breiling and Lyko, 2015).
DNA methylation at CpG dinucleotides is a well-studied epigenetic mechanism, defined as a heritable and enzyme-induced chemical modification of DNA
, not altering the DNA sequence (Wu et al., 2007).
The specific signature results from a chemical modification of DNA
called methylation, which can control the expression of genes like a dimmer on a light switch.
When colon, lung, breast, stomach and endometrial cancer is present, a "striking" chemical modification of DNA
occurs, said researchers from the National Human Genome Research Institute (NHGRI) in the US.
Kinetin is believed to develop in cellular DNA as a product of the oxidative, secondary modification of DNA
Compared with living people, Neandertals and ancient Siberians known as Denisovans had slightly different patterns of DNA methylation --a chemical modification of DNA
that doesn't change the information in genes but helps control gene activity.
The genome is programmed by the epigenome, which is composed of chromatin and a covalent modification of DNA
The methylation of P16 MGMT and hMLH1 was determined by the method of methylation-specific PCR after sodium bisulfate modification of DNA
(Wang et al.