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factor IX (human)

AlphaNine SD, Immune VH (CA), Mononine

factor IX (recombinant)

BeneFix

factor IX complex

Bebulin VH, Defix (UK), Hipfix (UK), Octaplex (CA), Profilnine SD, Proplex T (heat-treated), Replenine (UK)

Pharmacologic class: Blood modifier

Therapeutic class: Antihemophilic

Pregnancy risk category C

Action

Converts fibrinogen to fibrin, increasing levels of clotting factors

Availability

Powder for injection: Various strengths; units specified on label

Indications and dosages

Factor IX deficiency (hemophilia B or Christmas disease); anticoagulant overdose

Adults and children: Dosage individualized; drug administered I.V. Use following equations to calculate approximate units needed:

Human product-1 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Recombinant product-1.2 units/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Proplex T-0.5 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Off-label uses

• Hepatic dysfunction

• Esophagitis

• Unspecified GI hemorrhage (human product)

Contraindications

• Hypersensitivity to mouse or hamster protein (with BeneFix)

• Fibrinolysis

Precautions

Use cautiously in:

• recent surgery

• pregnant patients

• children younger than age 6 (safety and efficacy not established).

Administration

Give by slow I.V. infusion. Average infusion rate is 100 units (2 to 3 ml)/minute; don't exceed 10 ml/minute.

• If prescribed, administer hepatitis B vaccine before giving factor IX.

• Know that dosage is highly individualized according to degree of factor IX deficiency, patient's weight, and bleeding severity.

• Don't use glass syringe. Don't shake reconstituted solution or mix with other I.V. solutions.

Adverse reactions

CNS: light-headedness, paresthesia, headache

CV: blood pressure changes, thromboembolic reactions, myocardial infarction (MI)

EENT: allergic rhinitis

GI: nausea, vomiting

Hematologic: disseminated intravascular coagulation (DIC)

Respiratory: pulmonary embolism

Skin: rash, flushing, diaphoresis, pruritus, urticaria

Other: altered taste, fever, chills, burning sensation in jaw and skull, pain at I.V. injection site, hypersensitivity reactions including anaphylaxis

Interactions

Drug-drug. Aminocaproic acid: increased risk of thrombosis

Patient monitoring

• Be aware that factor IX complex may transmit hepatitis.

• Closely monitor vital signs during infusion.

Observe for hemolytic reaction. If it occurs, stop infusion, flush line with saline solution, and notify prescriber immediately.

• Monitor I.V. injection site closely.

Monitor coagulation studies closely. Know that drug may cause thromboembolic disorders, including MI and DIC.

Patient teaching

• Inform patient that drug may transmit diseases.

Tell patient to immediately report signs and symptoms of hypersensitivity reaction, including rash, hives, tightness in chest, wheezing, shortness of breath, and swelling of throat or lips.

Advise patient to immediately report unusual bleeding or bruising.

• Caution patient to avoid activities that can cause injury.

• Tell patient to wear medical identification stating that he has a blood-clotting disorder.

• Instruct patient to notify surgeon or dentist of his blood-clotting disorder before surgery or invasive dental procedures.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

human

(hyo͞o′mən)
n.
A member of the primate genus Homo, especially a member of the species Homo sapiens, distinguished from other apes by a large brain and the capacity for speech.
adj.
Of, relating to, or characteristic of humans: the course of human events; the human race.

hu′man·hood′ n.
hu′man·ness n.

human

[h(y)o̅o̅′mən]
Etymology: L, humanus
a member of the genus Homo and particularly of the species H. sapiens.

human

see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.

Patient discussion about human

Q. I am a man with breast cancer. Hello friends, you might have heard about breast cancer in women but here I am a man with breast cancer. Is Herceptin licensed to treat me?

A. Hi, what were your symptoms and when did you discover you had breast cancer?

Q. what are the basics products we as a humans, need to have in our diet?

A. A regular healthy diet should be comprised of a 40-50% carbohydrate (bread, rice, etc.), 30-40% protein (dairy, meat, chicken, fish) and 20% fat. Other important ingredients are fruit and vegetables, that contain large amounts of fibers and vitamins.

Q. Is there a difference between a man's diet and a woman's diet? let say for the point of it the weight the same and they are in the same age .

A. no one should have the same exact diet, you need to find what works for you and helps you achieve your goals.

the base of the diet could be the same, for example burn calories then you consume. But other wise, find what works for you.

More discussions about human
References in periodicals archive ?
The need for BE Modern Man is both urgent and obvious, as mainstream media persistently relegates the narrative of men of color to a limited number of one-dimensional personas: athlete, entertainer, victim, or perpetrator.
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Paying careful attention to detail and subtext and drawing support from ancient and modern scholars, Goodman paints us a portrait of a lonely, loveless and surprisingly modern man, set apart from the rest of the world and doomed from his miraculous conception to fulfill a Divine mission he neither understands nor has the power to preempt.
Instead, Gaudium et spes should be] read more through the lens of dc Lubac's [book] The drama of atheistic humanism; then, I think, there is a project of reaching out to so-called modern man and helping him to find himself by promoting John Paul II's theology of the body; the Trinitarian anthropology of the encyclicals Redemptor Hominis, Dives in Misericordia, and Dominum et Vivificantem [The Redeemer of man, 1979; On mercy, 1981; On the Holy Spirit, 1983]; and the values of the Gospel of Life in Evangelium vitae and Veritatis splendor [Gospel of Life--that project has really only just begun and has a long way to go before it starts to bear fruit.
This view of the modern man, who is unsure of himself, unsure of what is right and wrong, and fighting "inner demons," is the genesis of the homosexual "cowboys" in Brokeback Mountain, touted as "the year's most daring love story.
Other titles by Seyyed Hossein Nasr include updated and revised editions of Ideals and Realities of Islam (2001), Islam and the Plight of Modern Man (2002), and his comprehensive exposition A Guide to the Modern World (1994).
Rather than wanting a homemaker who thinks more about cup-cakes than canoodling, modern man is after a sexually- confident woman who is not shy about paying her own way.
The price of being a thoroughly modern man was yesterday costed at more than pounds 8,000.
The Sabbath: Its Meaning for Modern Man (New York: Noonday Press, 1994).

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