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Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  


said of a disease or condition that interferes with normal activities, such as eating and ambulation, without completely blocking them out.

Patient discussion about moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

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References in periodicals archive ?
Also, the final two versions failed to reveal any statistical effects related to closeness of one's most recent election (LAST), the moderateness of one's state-level electorate (CLINT), or cohort differences among those facing re-election after the 107th Congress and those who do not face re-election at that time (RELECT).
The rejection of a distinct moral point of view casts doubts on the way Scheffler pursues his inquiry into the moderateness of morality.
Al Yahya and his books about the Arabian Peninsula, the Kingdom of Saudi Arabia, moderateness, peace and dialogue, wishing him all success.
11 (BNA): Parliament and Information Affairs Minister, Isa bin Abdulrahman Al Hammadi, stressed the importance of the role of the media in protecting national security of the Arab Gulf Cooperation Council (GCC) states and preservation of their cultural and civilisational identity as well as safeguarding civic and societal peace besides boosting public awareness of respecting the law, spreading moderateness, tolerance, and shunning strife, hate, sectarian and racial discrimination.
The newspaper stressed the considerable importance of Bahrain for India and likewise India's considerable importance to Bahrain which is nothing new as their bilateral relations have extended over the centuries in the same manner of calm, peaceful and friendly relations as a result of moderateness and equilibrium policies.
The Institution stressed the need to protect the democratic path and to maintain atmospheres of co-existence, moderateness and acceptance of the other such features for which Bahrain has always been known.
Shura Council hails HM the King's Speech, invites religious leaders to rationalize discourse and focus on moderateness.
The Minister praised the role of Al-Azhar Islamic thinkers and professors who embrace moderateness and tolerance, and he praised the leading role of Egypt in all fields, especially those that brings together the nation's thinkers and academicians who will discuss and advise on the affairs and issue of the nation to ensure the nation's advancement, prosperity and leadership and to come up with successful solutions, remedies and initiatives.
SCIA: Bahrain known since ancient times for moderateness and equilibrium.
Foreign Minister: Bahrain upholds policy of moderateness, tolerance in the community.
Justice" urges orators to adopt moderateness and keep aloof from instigation of sectarian strife.