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Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Patient discussion about Moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

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References in periodicals archive ?
Also, the final two versions failed to reveal any statistical effects related to closeness of one's most recent election (LAST), the moderateness of one's state-level electorate (CLINT), or cohort differences among those facing re-election after the 107th Congress and those who do not face re-election at that time (RELECT).
The rejection of a distinct moral point of view casts doubts on the way Scheffler pursues his inquiry into the moderateness of morality.
The committee will study the concept of moderateness from various perspectives primarily the relationship of the individual person with Almighty Allah and his interaction within the community based upon fairness and justice and keenness on social stability and peace to consolidate the foundations of such values, Shaikh Rashid said.
"This is not an angry protest, like the ones in 1990 and 1996 - it inspires respect with its moderateness, something that those in power cannot but take into account," said Parvanov with respect to ongoing rallies against the Oresharski cabinet.
People can reinforce self-concepts of moderateness by rejecting what they perceive to be an extreme comparison (Tourangeau & Rasinski, 1988).
oAll of us are responsible for spreading our culture and moderateness in the world.
moderateness, he said and noted that the conference sessions touched on
The skeptical style of politics, Oakeshott argues here, while eminently suitable to static conditions of society, is "sluggish" and unprepared when it comes to genuine emergencies; and in its moderateness, it is incapable of evoking love or gratitude from its subjects.
He elaborated on the principles of his foreign policy, and said, "In the discourse of moderateness, foreign policy means protecting national security, securing national interests and all-out and targeted development of the country." In relevant remarks earlier this month, Rouhani had underlined that expansion of ties with the neighboring countries as well as establishment of peace and stability in the region will be a top priority of his administration.
He described the suspicious calls to "internationalize the Two Holy Mosques" as unethical errors that bespeak of malice, and political bankruptcy and ignorance about the historic role of the Kingdom of Saudi Arabia in spreading the Islamic call and the values of moderateness and fairness, establishing Islamic educational centres and providing humanitarian and relief assistance worldwide.
Al Qubaisi emphasised Al Azhar's role as a key religious institution that advocates and promotes the values of tolerance, peace, moderateness, respect for women and dialogue among different beliefs.
Al Yahya and his books about the Arabian Peninsula, the Kingdom of Saudi Arabia, moderateness, peace and dialogue, wishing him all success.