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proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

moderate

said of a disease or condition that interferes with normal activities, such as eating and ambulation, without completely blocking them out.

Patient discussion about moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

More discussions about moderate
References in classic literature ?
For if a man had always on his arrival in this world dedicated himself from the first to sound philosophy, and had been moderately fortunate in the number of the lot, he might, as the messenger reported, be happy here, and also his journey to another life and return to this, instead of being rough and underground, would be smooth and heavenly.
His caddy, who had teed the ball, and who had regarded the proceedings with a moderately tolerant air, felt called upon at last to interfere.
The kitchen garden pleased him hugely, the flowers moderately, but the pigeons and the poultry, and the stables when he was allowed to visit them, were delightful objects to him.
Catherick is a decent, well-behaved, respectable woman; middle-aged, and with the remains of having been moderately, only moderately, nice-looking.
It is bound, too, in common humanity, to declare that no man shall be taken on board without his stock of provisions being previously inspected by some proper officer, and pronounced moderately sufficient for his support upon the voyage.
and if something had kept us apart then, when I was moderately thriving, and when you were poor; I might have met your noble offer of your fortune, dearest girl, with other words than these, and still have blushed to touch it.
screamed Charlotte: seizing Oliver with her utmost force, which was about equal to that of a moderately strong man in particularly good training.
ySTANBUL (CyHAN)- In a statement in Parliament on Tuesday, Defense Minister ysmet Yylmaz revealed that almost 90 percent of the buildings belonging to the Defense Ministry have been moderately or heavily damaged due to earthquakes and need to be demolished or almost entirely rebuilt.
The quake also left 5,516 houses damaged heavily, 2,750 moderately and 5,593 lightly.
A nationally representative sample of men and women from across the four provinces was asked "Generally, how happy do you consider yourself; extremely happy, moderately happy or unhappy?
20% say the US should be moderately more involved with the international peacekeeping organization, and 15.
Abbott today announced that the European Commission (EC) has approved HUMIRAA (adalimumab) for the treatment of moderately active Crohn's disease (CD) in adult patients who have had an inadequate response to conventional therapy.

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