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Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Patient discussion about Moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

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References in periodicals archive ?
The company added that RINVOQ is an oral, small molecule JAK inhibitor being studied for moderately to severely active rheumatoid arthritis and other immune-mediated diseases.
The researchers found that when extrapolated to the population, an estimated 3.3 million older adults developed incident moderately severe dementia.
Osaka, Japan, May 22, 2019 -- Takeda Pharmaceutical Company Limited ("Takeda") (TSE: 4502/NYSE: TAK) today announced that it has obtained approval from the Ministry of Health, Labour and Welfare (MHLW) for an additional indication for Entyvio[R] (generic name: vedolizumab, development code: MLN0002) for the treatment of adult patients with moderately to severely active Crohn's disease (CD) in Japan.
The SWS said that net agreement with the proposal was highest in the Visayas at +47 which was 'very strong,' followed by Mindanao at +25 which was 'moderately strong.'
The net agreement with the proposal was highest in Visayas at "very strong" +47 (69 percent agree, 21 percent disagree), followed by Mindanao at "moderately strong" +25 (51 percent agree, 26 percent disagree), Metro Manila at "moderately strong" +17 (53 percent agree, 36 percent disagree), and rest of Luzon at "neutral" -6 (42 percent agree, 48 percent disagree).
"Given the inflation outlook, monetary policy could also be adjusted from its moderately tight stance toward a neutral stance in Russia," the report added.
Initial clinical manifestation of renal involvement in diabetes is an increase in albumin excretion which is called moderately increased albuminuria (formerly called microalbuminuria)which is defined as urinary albumin excretion between 30 and 300 mg/day3.
In Herzegovina, on Friday, May 25, the weather will be moderately, in Bosnia mostly cloudy.
patula, Eucalyptus nitens, and grass) and soil drainage class (poorly, moderately, and freely drained soils) areas.
The BitSS scale demonstrated good convergent validity, it correlated strongly with the rPBS, and moderately with the rRLI and the ISS.
According to a study led by American Academy of Neurology, women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia decades later, compared to women who were moderately fit,reported health news.
(not at all, a little, moderately, quite a bit, extremely)

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