mixed-lineage leukemia


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mixed-lineage leukemia

Abbreviation: MLL
An aggressive, primarily childhood leukemia caused by the translocation of a gene from chromosome 11 to a region that overproduces fusion proteins.
See also: leukemia
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Background/Objective: The mixed-lineage leukemia gene, (MLL), breaks and fuses to one of >50 different translocation partner genes in several subtypes of de novo human acute leukemia.
ALL ALL (B) 4 ALL (T) 7 AML ApML, (AML with t[15;17][q22;q12] [PML/ RARA] and variants) 2 Acute myeloblastic leukemia, with 11q23 (MLL) abnormalities 4 AML, minimally differentiated 1 AML, without maturation 4 Acute myelomonocytic leukemia 6 Acute monoblastic leukemia 1 Acute erythroid leukemia 1 Biphenotypic acute leukemia 2 Abbreviations: ALL, acute lymphoblastic leukemia/lymphoma;ALL (B), precursor B-lymphoblastic leukemia/lymphoma;ALL (T), precursor T-lymphoblastic leukemia/lymphoma; AML, acute myeloid leukemia; ApML, acute promyelocytic leukemia;MLL, myeloid/lymphoid or mixed-lineage leukemia gene;PML, promyelocytic leukemia gene; RARA, retinoic acid receptor, alpha gene.

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