mixed connective tissue disease


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to mixed connective tissue disease: polymyositis, Undifferentiated Connective Tissue Disease

mixed connective tissue disease

 
a combination of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis, and marked serologically by the presence of antibody against extractable nuclear antigen.

mixed connective tissue disease

A connective tissue disease with features of SLE, dermatomyositis, rheumatoid arthritis Clinical Pleuritis, Raynaud's phenomenon, sclerodactyly, good response to steroids Lab MCTD has a unique speckled nucleolar pattern due to presence of a specific circulating antibodies to ribonucleoprotein; no antibodies to double-stranded DNA and Sm antigen. See Antinuclear antibodies, 'Chinese menu' diseases, Overlap syndrome.

mix·ed con·nec·tive tis·sue dis·ease

(mikst kŏ-nek'tiv tish'ū di-zēz')
Disorder with overlapping features of various systemic connective-tissue diseases and with serum antibodies to nuclear ribonucleoprotein.

mixed connective tissue disease

A condition that combines some of the features of SYSTEMIC LUPUS ERYTHEMATOSUS, POLYMYOSITIS and progressive SYSTEMIC SCLEROSIS. The blood contains high levels of ANTINUCLEAR ANTIBODY. There are skin changes similar to DERMATOMYOSITIS, swelling of the fingers with RAYNAUD'S phenomenon, muscle weakness and arthritis involving several joints. The condition responds well to treatment with corticosteroid drugs and the outlook is favourable.
References in periodicals archive ?
Classification and diagnostic criteria for mixed connective tissue disease. In: Mixed Connective Tissue Disease and Anti-nuclear antibodies, Kasukawa R, Sharp G (Eds), Elsevier, Amsterdam 1987; p.33.
Clinical usefulness of autoantibodies to U I snRNP proteins in mixed connective tissue disease and systemic lupus erythematosus.
Pulmonary manifestations of scleroderma and mixed connective tissue disease. Clin Chest Med.
Fifty-seven (30%) patients had Sjogren syndrome; 50 (26.5%) had systemic lupus erythematosus; 7 (3.7%) had systemic lupus erythematosus and/or Sjogren syndrome; 11 (6%) had subacute cutaneous lupus, discoid lupus, drug-induced lupus, or neonatal lupus; 6 (3%) had mixed connective tissue disease; 15 (8.5%) had dermatomyositis, scleroderma, rheumatoid arthritis, polymyalgia rheumatica, or undifferentiated systemic disease; and 42 (21.3%) had a medical condition other than a systemic (undifferentiated) rheumatic disease (i.e., not Sjogren syndrome and/or any form of lupus, mixed connective tissue disease, dermatomyositis, scleroderma, or rheumatoid arthritis).
The commonest disorder was RA seen in 458(76%) patients, followed by SLE in 42(7%), AS in 32(5.3%), mixed connective tissue disease (MCTD) in 22(3.6%), systemic sclerosis in 12(2%); juvenile RA (JRA) in 7(1.2%), and anti- phospholipid antibodies (APLA) in 6(1%) patients.
Maternal mixed connective tissue disease and offspring with chondrodysplasia punctata.
Clinicians wondered whether it might be related to the patient's mixed connective tissue disease; or to a drug, or to both a drug and connective tissue disease.
The chapter on autoimmune disease and serology was not included in the current edition, and related topics such as anti-neutrophil cytoplasmic antibody, anti-nuclear antibody, dermatomyositis, Raynaud disease, and mixed connective tissue disease were not identified in the index.
Anti-SSA and anti-SSB antibodies are found in Sjogren Syndrome (SS), anti-Sm antibodies are found in systemic lupus erythematosus (SLE), anti-RNP antibodies are found in mixed connective tissue disease (MCTD), and anti-Scl-70 antibodies are found in scleroderma.