mithramycin

plicamycin

 [pli″kah-mi´sin]

an antineoplastic antibiotic produced by Streptomyces plicatus that binds to DNA and inhibits RNA synthesis; it is used for treatment of advanced testicular carcinoma; major side effects are thrombocytopenia and hemorrhagic diathesis that can be life-threatening. It also has an inhibiting effect on osteoclasts and is used to treat hypercalcemia and hypercalciuria caused by metastatic malignancy. Administered intravenously. Formerly called mithramycin.

Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mith·ra·my·cin

(mith'ră-mī'sin),

An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.

Synonym(s): aureolic acid, mitramycin

Farlex Partner Medical Dictionary © Farlex 2012

mithramycin

A drug that reduces bone metabolism and can be useful in the treatment of PAGET'S DISEASE and HYPERCALCAEMIA.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

mith·ra·my·cin

(mith'ră-mī'sin)

An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.

Medical Dictionary for the Dental Professions © Farlex 2012