mithramycin

plicamycin

 [pli″kah-mi´sin]

an antineoplastic antibiotic produced by Streptomyces plicatus that binds to DNA and inhibits RNA synthesis; it is used for treatment of advanced testicular carcinoma; major side effects are thrombocytopenia and hemorrhagic diathesis that can be life-threatening. It also has an inhibiting effect on osteoclasts and is used to treat hypercalcemia and hypercalciuria caused by metastatic malignancy. Administered intravenously. Formerly called mithramycin.

mith·ra·my·cin

(mith'ră-mī'sin),

An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.

Synonym(s): aureolic acid, mitramycin

mithramycin

A drug that reduces bone metabolism and can be useful in the treatment of PAGET'S DISEASE and HYPERCALCAEMIA.

mith·ra·my·cin

(mith'ră-mī'sin)

An antibiotic produced by Streptomyces argillaceus and S. tanashiensis; possesses antineoplastic activity.