Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb.
HE staining showed that the OB was a hierarchical structure, the layers from the outside to the inside were the olfactory nerve layer, glomerular layer (GL), external plexiform layer (EPL), mitral cell layer (MCL), internal plexiform layer, and granular cell layer (GC1).
Imai and colleagues report that they were also able to visualize in three dimensions the wiring of mitral cells
in the olfactory bulb, which is involved the detection of smells, at single-fiber resolution.
Six weeks after transplantation, however, more bone marrow-derived microglial cells were observed in the olfactory bulbs of the test animals where the degeneration of mitral cells
was still in progress.
Because mitral cells are situated close to each other and have the same job description, Baldwin expected their info-sending axons to look similar.
It was the bizarrely unpredictable and diverse behavior of mitral cells that alerted Nathan Urban to the possibility that variety might help the brain do its job.
MUTUAL EXCITATION AMONG OLFACTORY BULB MITRAL CELLS
REVEALED BY RECURRENCE TIME HISTORY MAPPING (RTHM) **, Alexandra Radu *, Maame Boateng *, Henaa Razzak * and Barry K.
These cells then transmit electrical signals to the olfactory bulb, where mitral cells
forward the signals to the brain for processing.
OB output is encoded in the spiking patterns of the primary OB neurons--the mitral and tufted mitral cells
(MTCs)--which project directly to higher cortical centers.
By placing an electrical probe into individual excitatory neurons called mitral cells
and exposing them to a complex computer-controlled noise stimulus, the researchers were able to determine how each cell responded.