The first OB neurons infected with the rabies virus were observed at 80 hours post-inoculation (p.i.) and corresponded, due to their location and size, to mitral cells (Fig.
The first neurons infected were mitral cells. This is explained because they are the projection neurons that communicate the OB with the cerebral cortex.
Interestingly, mitral cells do not stain with NeuN marker (Figure 1(c)).
As soon as the animals detect a food odor, an increase in the electrical activity of the mitral cells is observed .
Dopaminergic modulation of mitral cells
and odor responses in the zebrafish olfactory bulb.
Imai and colleagues report that they were also able to visualize in three dimensions the wiring of mitral cells
in the olfactory bulb, which is involved the detection of smells, at single-fiber resolution.
Six weeks after transplantation, however, more bone marrow-derived microglial cells were observed in the olfactory bulbs of the test animals where the degeneration of mitral cells
was still in progress.
The particular neurons Baldwin studies, called mitral cells
, are smell go-betweens, carrying odor information from scent-detecting cells in the nose to higher brain regions.
MUTUAL EXCITATION AMONG OLFACTORY BULB MITRAL CELLS
REVEALED BY RECURRENCE TIME HISTORY MAPPING (RTHM) **, Alexandra Radu *, Maame Boateng *, Henaa Razzak * and Barry K.
By age 95, you have less than a quarter of the mitral cells
that you had when you were 25.
OB output is encoded in the spiking patterns of the primary OB neurons--the mitral and tufted mitral cells
(MTCs)--which project directly to higher cortical centers.
By placing an electrical probe into individual excitatory neurons called mitral cells
and exposing them to a complex computer-controlled noise stimulus, the researchers were able to determine how each cell responded.